Mechanism of Relieves insomnia Effect of Jiaotai Pills Based on Network Pharmacology

Corresponding author: Yuan Zhenzhong, wzyzz2008@126.com

DOI: 10.12201/bmr.202408.00069

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  Abstract: Object: To explore the potential mechanism of the relieves insomnia effect of Jiaotai Pills by virtue of network pharmacology and molecular docking. Methods: The active ingredients of Jiaotai Pills are obtained by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine (TCMIP). Related targets of jaotaiwan were predicted by SwissTargetPrediction. The potential targets associated with insomnia were retrieved from DisGeNET、DrugBank. Venny was employed to identify the common targets shared by active components, insomnia, and core nodes, and the key components and key targets were screened by further topological analysis. The key components and key targets were analyzed by the Network Analysia plug-in of Cytoscape and the core components were screened out. The protein-protein interaction (PPI) network and the core targets were built by STRING. Gene ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment were performed in DAVID.AutoDockTools1.5.7 was used for the molecular docking between the key targets and the corresponding key components. Apply Pymol to visualize the results. Results: A total of 5 active components of Jiaotai Pill were screened, including Berberine, Limonin, Obacunone. Moupinamide, Palmatine, Quercetin，， and core targets such as SLC6A4, DRD2, CHRNA4, TNF, and PTGS2 were screened. The signaling pathways of Jiaotai pills for insomnia mainly concentrated in regulating 5-hydroxytryptaminergic synapses and dopamine synapses. Molecular docking showed that core components Berberine, Limonin, and Obacunone and core targets SLC6A4, DRD2, CHRNA4, TNF, and PTGS and so on were well docked. Conclusion: Berlambine、Llimonin、Obacunone in Jiaotai Pills through multiple mechanisms to treat insomnia by affecting the expression of SLC6A4, DRD2, TNF, CHRNA4, and PTGS2.

  Key words: Jiaotai Pills; insomnia; network pharmacology; molecular docking; mechanism of action

  Submit time: 29 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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