通讯作者: 王凯华, Wangkaihua1119@163.com

DOI：10.12201/bmr.202504.00009

Based on data mining to explore Wu Zihuis prescription for treating insomnia

• 摘要：目的:通过数据挖掘技术分析吴子辉治疗失眠的用药规律。方法：整理2020年6月至2024年3月广西中医药大学附属国际壮医医院吴子辉门诊收治诊断为失眠的医案，运用古今医案云平台V2.3.9对录入医案数据标准化处理后进分别对处方药物进行统计分析，聚类分析及复杂网络分析，总结处方用药经验及组方规律。结果：共纳入医案131份，涉及143味中药，归纳出药性以寒、平为主，药味以甘、苦、辛为主，归经以心、肝二经为主以及高频药物20味为白芍、白术、女贞子等；聚类分析得出5个聚类处方；药物之间的复杂网络分析可得出核心药物处方为逍遥散合二至丸加减，中药证型及药物进行复杂网络分析可得出失眠实证（肝火扰心证及痰火扰心证）的两个核心中药处方。结论：吴子辉在治疗失眠时以疏肝解郁、清热泻火、养心安神，兼以补益脾肾为治疗原则。

  关键词： 失眠; 处方规律; 吴子辉

   

  Abstract: Objective: To analyze the drug use rule of Wu Zihui in treating insomnia by data mining technology. Method: Medical records diagnosed as insomnia admitted to Wu Zihui Outpatient Department of International Zhuang Medical Hospital Affiliated to Guangxi University of Traditional Chinese Medicine from June 2020 to March 2024 were collected. After standardized processing of the input medical records data on the cloud platform V2.3.9 of ancient and modern medical records, statistical analysis, cluster analysis and complex network analysis were carried out to summarize the experience of prescription medication and the rules of prescription formulation. Results: A total of 131 medical records were included, involving 143 traditional Chinese medicines. The main medicinal properties were cold and ping, the main medicinal tastes were sweet, bitter and xin, the main classics were heart and liver, and the 20 high-frequency medicinal tastes were Paeony, Baizhu and Fructus ligustris. Five cluster prescriptions were obtained by cluster analysis. The complex network analysis between drugs can conclude that the core drug prescription is Xiaoyao SAN combined with Erzhi pills, and the complex network analysis of Chinese medicine syndromes and drugs can obtain the two core Chinese medicine prescriptions of insomnia (liver fire disturbing heart syndrome and phlegm fire disturbing heart syndrome). Conclusion: Wu Zihui treated insomnia with the principles of soothing the liver and relieving depression, clearing heat and expelling fire, nourishing the heart and calming the mind, and tonifying the spleen and kidney.

  Key words: insomnia; prescription rule; Wu Zihui

  提交时间：2025-04-07

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• 序号	提交日期	编号	操作
  1	2025-03-31	bmr.202504.00009V1	下载

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