通讯作者: 殷军波, qdyjb9131@163.com

DOI：10.12201/bmr.202501.00017

A controlled study of pregabalin combined with escitalopram in patients with major depressive disorder

• 摘要：目的：研究艾司西酞普兰与普瑞巴林联合应用于重度抑郁障碍患者时的临床效果与安全性状况。方法：选取 61 例于2023年6月1日-2024年2月1日青岛市精神卫生中心就诊的重度抑郁障碍患者（Major depressive disorder，MDD）（有 1 例脱落），借助随机数分组方式将其划分为对照组（艾司西酞普兰，n = 30）以及实验组（普瑞巴林联合艾司西酞普兰，n = 30），整个疗程共 6 周。分别在治疗前、治疗第 2 周、第 4 周、第 6 周进行相关评估，并且在治疗前、治疗第 6 周检查血常规、心电图、生化组合，利用汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁 17 项量表 (HAMD - 17)、治疗时出现的症状量表（TESS）对疗效与安全性予以评价。结果：两组患者在入组前的 HAMD - 17、HAMA 得分经比较，其差异无统计学意义 (P > 0.05，t = 0.615)。在治疗 2 周、4 周、6 周后得分均较治疗前有所降低。治疗第 2 周末，实验组 HAMD-17、HAMA 评分显著低于对照组 (P < 0.05)。治疗第 4 周末，实验组 HAMD - 17、HAMA 评分依旧低于对照组 (P < 0.05)。治疗第 6 周末，实验组 HAMD - 17、HAMA 评分同样低于对照组 (P < 0.05)。两组的总不良反应发生率相互比较，差异无统计学意义 (P > 0.05)。结论：普瑞巴林合并艾司西酞普兰对MDD患者可以更快、更有效地缓解焦虑症状及抗抑郁疗效。

  关键词： 普瑞巴林; 艾司西酞普兰 重度抑郁障碍; 广泛性焦虑障碍; 

   

  Abstract: Abstract: To explore the clinical efficacy and safety of escitalopram combined with pregabalin in patients with major depressive disorder. Methods: Sixty patients with recurrent depression were selected and divided into an experimental group (pregabalin combined with escitalopram, n = 30) and a control group (escitalopram, n = 30). The treatment course was 6 weeks. Before treatment and at the 2nd, 4th, and 6th weeks of treatment,Hamilton Depression Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Treatment Emergent Symptom Scale (TESS) were used to evaluate efficacy and safety. Results: Before enrollment, there was no statistically significant difference in the scores of HAMD-17 and HAMA between the two groups (t = 0.615, P > 0.05).The scores after 2, 4, and 6 weeks of treatment were all lower than those before treatment. At the end of the 2nd week after treatment, the HAMD-17 and HAMA scores of the experimental group were lower than those of the control group (P<0.05). At the end of the 4th week after treatment, the HAMD-17 and HAMA scores of the experimental group were lower than those of the control group (P<0.05). At the end of the 6th week after treatment, the HAMD-17 and HAMA scores of the experimental group were lower than those of the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups (P>0.05). Conclusion: Pregabalin combined with escitalopram can relieve anxiety symptoms and have antidepressant efficacy more quickly and effectively in patients with MDD.

  Key words: Pregabalin; Escitalopram; Major Depressive Disorder; Generalised anxiety disorder

  提交时间：2025-01-06

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• 序号	提交日期	编号	操作
  1	2024-12-07	bmr.202501.00017V1	下载

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