通讯作者: 曾波涛, zbt01@126.com

DOI：10.12201/bmr.202412.00022

Study on self-injurious and suicidal behavior, non-enzymatic antioxidants and thyroid hormones in adolescents with depressive disorder

• 摘要：目的：分析青少年抑郁症患者的自伤、自杀行为与非酶类抗氧化物水平、甲状腺激素水平的关系。方法：采用纵向横断面研究，选取2023年8月~2024年5月青岛市精神卫生中心住院的93例青少年抑郁症患者为研究对象，分为抑郁症伴自伤行为组（自伤组）、抑郁症伴自杀行为组（自杀组）及抑郁症不伴自伤自杀行为组（抑郁组）。检测患者入院时及治疗8周后血浆非酶类抗氧化物及甲状腺激素水平，采用汉密尔顿抑郁量表、汉密尔顿焦虑量表评定患者临床症状。比较3组患者血浆非酶类抗氧化物、甲状腺功能水平及量表评分差异。结果：相较于抑郁组，自伤组和自杀组的基线尿酸水平更低（P=0.039,P=0.010）。治疗8周后自伤组游离三碘甲状腺原氨酸水平高于自杀组（P=0.040），3组患者汉密尔顿抑郁量表、汉密尔顿焦虑量表评分均下降（F=3.827,P=0.025;F=3.414,P=0.040），校正后汉密尔顿抑郁量表评分差异无统计学意义（P＞0.05），自杀组汉密尔顿焦虑量表评分高于抑郁组（P=0.047）。治疗前后相比较，抑郁组、自伤组、自杀组患者治疗后促甲状腺激素水平均升高（t=-2.038, P=0.050;t=-2.407, P=0.023; t=-2.278, P=0.030），汉密尔顿抑郁量表及汉密尔顿焦虑量表评分均下降（P＜0.001），自杀组患者治疗后总胆红素、游离三碘甲状腺原氨酸水平下降，尿酸水平增加（t=2.135, P=0.041; t=2.876, P=0.007; t=-2.671, P=0.012），抑郁组患者治疗后游离甲状腺素水平下降（t=2.708, P=0.011）。结论：非酶类抗氧化物可作为青少年抑郁症患者自伤、自杀行为的潜在生物学指标。

  关键词： 青少年; 抑郁症; 自杀行为; 自伤行为; 非酶类抗氧化物; 甲状腺激素

   

  Abstract: Abstract: 【Objective】This study investigates the correlation between self-injurious and suicidal behavior in adolescents with depressive disorder and their non-enzymatic antioxidants and thyroid hormones.【Methods】A total of 93 adolescent patients with depressive disorder who were hospitalized at the Qingdao Mental Health Center from August 2023 to May 2024 were selected as the research subjects. The patients were divided into three groups: a group without either self-injurious or suicidal behavior ,a group with self-injurious behavior and a group with suicidal behavior. Levels of serum albumin (ALB), total bilirubin (TBIL), uric acid (UA), free triiodothyronine (FT3), free thyroxine (FT4), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured at admission and again after two weeks of treatment. Clinical symptoms were assessed using the Hamilton Depression Scale (HAMD) and the Hamilton Anxiety Scale (HAMA). Compare the differences in the levels of the above clinical indicators. 【Results】Compared with the depression group, baseline UA levels were lower in both the self-injurious and suicidal behavior groups (P=0.039, P=0.010). After 8 weeks of treatment, FT3 levels were higher in the self-injurious group than in the suicidal behavior group (P=0.040), and both HAMD and HAMA scores decreased in all patients(F=3.827, P=0.025; F=3.414, P=0.040). After correction, there were no statistically significant differences in HAMD scores among all groups (P>0.05), while HAMA scores were higher in the suicidal behavior group than in the depression group (P=0.047). Compared to baseline levels, TSH levels increased（t=-2.038, P=0.050;t=-2.407, P=0.023; t=-2.278, P=0.030） and HAMD and HAMA scores decreased in all groups after treatment (P < 0.001). In the suicidal behavior group, TBIL and FT3 levels decreased, and UA levels increased after treatment (t=2.135, P=0.041; t=2.876, P=0.007; t=-2.671, P=0.012), while in the depression group, FT4 levels decreased after treatment (t=2.708, P=0.011).【Conclusions】Non-enzymatic antioxidants may serve as potential biological markers for adolescents with depressive disorder who exhibit self-injurious and suicidal behavior.

  Key words: Adolescent; Depressive disorder; Self-injurious behavior; Suicidal Behavior; Non-enzymatic antioxidants; Thyroid hormones

  提交时间：2024-12-07

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• 序号	提交日期	编号	操作
  1	2024-11-13	bmr.202412.00022V1	下载

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