通讯作者: 黄秋玲, 68861683@qq.com

DOI：10.12201/bmr.202411.00024

The relationship between hyperactivity behavior in children with attention deficit hyperactivity disorder and serum levels of thyroid-stimulating hormone

• 摘要：目的 探讨甲状腺功能与注意缺陷多动障碍(ADHD)儿童多动行为(HB)之间的关系,进一步了解导致ADHD风险增加的潜在因素,为儿童ADHD的治疗提供参考。方法 共134例符合研究标准的儿童ADHD患者作为研究对象,分为非HB组和HB组,通过单因素分析对其一般资料和常规实验室参数进行比较,通过二分类Logistic回归分析评估HB相关因素,最后通过Pearson直线相关分析和受试者工作特征(ROC)曲线研究HB与血清促甲状腺激素(TSH)的关系及TSH水平在区分ADHD儿童HB方面的潜在诊断价值。结果 两组病例的Lac(P=0.040)、TSH(P<0.001)水平的差异比较具有统计学意义,HB组病例明显高于非HB组；其中,TSH水平与HB独立相关,与多动指数(HI)得分呈正相关(r =0.668,P<0.001)；并且,TSH水平在区分ADHD儿童HB方面具有一定的价值,截断点为2.57μIU/ml (敏感度65.1%,特异度74.7%)。结论 该研究揭示了血清TSH水平与ADHD患儿的HB相关,并且呈正相关关系,同时可用于区分ADHD儿童多动行为。

  关键词： 注意缺陷多动障碍; 多动指数; 促甲状腺激素

   

  Abstract: Objective Exploring the relationship between thyroid function and hyperactive behavior (HB) in children with attention deficit hyperactivity disorder (ADHD), further understanding the potential factors contributing to increased risk of ADHD, and providing references for the treatment of ADHD in children. Methods A total of 134 children with ADHD who met the study criteria were enrolled as subjects and divided into non-HB group and HB group. General information and routine laboratory parameters were compared between the two groups using one-way analysis. HB-related factors were evaluated using binary logistic regression analysis. Finally, Pearson linear correlation analysis and receiver operating characteristic (ROC) curve were used to study the relationship between HB and serum thyrotropin (TSH) and the potential diagnostic value of TSH levels in distinguishing ADHD children with HB. Results The differences in Lac (P=0.040) and TSH (P<0.001) levels between the two groups of cases are statistically significant, with the HB group showing significantly higher levels compared to the non-HB group. Among them, TSH levels are independently associated with HB and positively correlated with the Hyperactivity Index (HI) score (r=0.668, P<0.001). Additionally, TSH levels have a certain value in distinguishing ADHD children with HB, with a cut-off point of 2.57 μIU/ml (sensitivity 65.1%, specificity 74.7%). Conclusion This study revealed a positive correlation between serum TSH levels and HB in children with ADHD, and it can be used to differentiate ADHD children with hyperactivity behavior.

  Key words: Attention Deficit Hyperactivity Disorder; Hyperactivity Index; Thyroid Stimulating Hormone

  提交时间：2024-11-11

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• 序号	提交日期	编号	操作
  1	2024-10-07	bmr.202411.00024V1	下载

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