The value of using ultrasound indicators of rectus femoris muscle combined with clinical data to evaluate PEW in MHD patients

Corresponding author: guo xin min, guo8186@126.com

DOI: 10.12201/bmr.202506.00032

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  Abstract: Objective: To explore the value of combining quantitative indicators of rectus femoris muscle obtained through ultrasound technology with clinical data in identifying protein energy depletion (PEW) in patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis (MHD). Methods: 90 CKD patients undergoing regular hemodialysis treatment at our hospitals nephrology department from November 2023 to August 2024 were selected and divided into an abnormal group (30 cases with PEW) and a control group (60 cases without PEW) according to PEW diagnostic criteria. Clinical indicators and quadriceps ultrasound quantitative data were measured and compared between the two groups. Independent predictors of PEW were screened through multivariate logistic regression analysis. A prediction model was constructed and ROC curves were drawn to evaluate its diagnostic performance. Results: Significant differences were observed between the PEW group and the control group in body mass index (BMI), serum albumin (ALB), age, gender, rectus femoris thickness (MT), and cross-sectional area (SCA) (all P<0.05). Multivariate analysis showed that BMI and rectus femoris thickness were independent factors affecting PEW in CKD patients. A diagnostic model based on these two indicators, Logit(P)=1/1+e^-(10.292-0.378×BMI-2.992×rectus femoris thickness),

  Key words: Ultrasonography; rectus femoris muscle; Protein Energy Expenditure; Chronic Kidney Disease; Maintenance Hemodialysis

  Submit time: 14 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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