Solving the problem: pathogenesis and prevention strategy of osteoporosis secondary to liver cirrhosis

Corresponding author: Wang Xiao-zhong＊, wxz125@sina.com

DOI: 10.12201/bmr.202412.00024

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  Abstract: Osteoporosis is a systemic bone disease characterized by low bone density and susceptibility to fractures. It is one of the complications of liver cirrhosis, which leads to a significantly increased risk of fracture in patients, significantly reduces the quality of life of patients and has a poor prognosis. Therefore, the secondary osteoporosis of liver cirrhosis should be detected as early as possible and actively prevented.In recent years, many studies have shown that its pathogenesis is inhibition of insulin-like growth factor-1 synthesis, sex hormone deficiency, hypogonadism, leptin, irisin, intestinal flora, activation disturbance of vitamin D3, abnormal increase of bilirubin, and high expression of cytokines, which all participate in the development process of cirrhosis related osteoporosis.In addition to general treatment and active treatment of the primary disease, anti-osteoporosis drugs are commonly used, including calcium, vitamin D, bisphosphonate, hormones, RANKL inhibitors, recombinant human parathyroid hormone, vitamin K and liver transplantation, etc. This article summarizes the research progress in the pathogenesis and treatment of cirrhosis related osteoporosis.

  Key words: cirrhosis, osteoporosis, pathogenesis, treatment

  Submit time: 8 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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