Correlation between psychological stress and metabolic-associated fatty liver disease

Corresponding author: LU Wenping, lvwenping301@126.com

DOI: 10.12201/bmr.202204.00003

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  Abstract: Objective To investigate the correlation between psychological stress and metabolically associated fatty liver disease (MAFLD), and to provide a basis for the new concept of psychological intervention in the treatment of MAFLD. Methods The medical history and physical examination data of people who underwent physical health examinations in the Department of Health Management Institute, PLA General Hospital from January 2017 to December 2020, were analyzed, and the PSS-14 Stress Perception Scale was used to assess psychological stress level of the participants in the past 1 month. The variables related to the prevalence of MAFLD were screened by χ2 test and univariate analysis. After adjusting for confounding factors, the variables with statistical significance in univariate analysis were included in logistic multivariate regression analysis. Results A total of 19,999 participants were included, of which the prevalence of MAFLD was 46.4% (9281/19999), the population with high-level psychological stress accounted for 34.5% (6908/19999), with an average age of 46.3, males among them accounted for 78.2% (5407/6908) and 21.8% (1501/6908) of females. Multivariate logistic regression analysis showed that psychological stress is a risk factor for MAFLD (OR=1.173,95% CI:1.093~1.259). Conclusion Psychological stress is a risk factor for MAFLD, and it is necessary to actively evaluate the psychological and mental health status of people with high hazards of MAFLD in clinical practice, to achieve early prevention and intervention.

  Key words: Metabolic-associated fatty liver disease; Psychological stress; Risk factors

  Submit time: 14 April 2022

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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