通讯作者: 王磊, max0126@126.com

DOI：10.12201/bmr.202510.00034

The Role of Gastrointestinal Tumor Markers and Inflammatory Indicators in the Diagnosis and Treatment of Esophageal Cancer

• 摘要：我国是食管癌高发国家，每年新发病例约占总新发病例的50%1。2022年国家癌症中心发布的全国癌症数据报告中显示当年我国食管癌新发病例22.40万，死亡病例18.75万，分别位居全球第七位和第五位2。近年来，随着医学技术的发展和人们健康意识的增强，食管癌患者生存率虽已显著提高，但由于现代社会致癌因素激增、医疗可及性差异，食管癌依然是严重威胁人类健康的恶性肿瘤之一。肿瘤的演变与转移是一个动态的过程，在此过程中，机体的蛋白质、核酸及相关代谢产物可能发生异常改变，因此发现这些具有潜在诊断或预测价值的标志物成为研究热点。当前，食管癌相关肿瘤标志物和炎症指标因检测简便、低成本和高安全性，使之成为食管癌研究的热点领域。本文以蛋白、脂质及炎症指标为方向，对食管癌相关标志物的研究进展进行综述。

  关键词： 食管癌；肿瘤标志物；炎症指标；诊断；预后预测; ; ; ; 

   

  Abstract: Esophageal cancer is the eighth most common type of cancer in the world and the sixth leading cause of cancer-related deaths. Because of its insidious and undetectable onset, it faces many complex difficulties and challenges in early prevention, diagnosis and treatment. At present, gastroscopy + pathological biopsy is the gold standard for the diagnosis of esophageal cancer, but it is not suitable as a screening examination for the population and is difficult to be popularized and applied because of its high cost, technical difficulty and invasiveness. Therefore, the search for one or a more convenient and effective diagnostic tool has become a research hotspot. Tumor markers and inflammatory markers, including proteins and nucleic acids, have gradually become a new direction in the research of esophageal cancer and other digestive tract tumors because of their simple, economical, convenient and reproducible detection methods. In recent years, significant progress has been made in the research on gastrointestinal tract-related tumor markers and inflammatory markers. New literature reports are constantly being published, which provide a new perspective for the early diagnosis and prognosis evaluation of esophageal cancer. The purpose of this article is to explore the application prospects of biomarkers suitable for early diagnosis and prognosis evaluation in the diagnosis and treatment of esophageal cancer, comprehensively analyze the latest research results, and review the research progress of biomarkers of esophageal cancer in recent years.

  Key words: esophageal cancer; tumor markers; Inflammatory markers; Diagnosis; Prognostic prediction

  提交时间：2025-10-21

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-08-17	bmr.202510.00034V1	下载

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