通讯作者: 袁昌丽, 593922462@qq.com

DOI：10.12201/bmr.202508.00037

Advances in Research on the Aggressive Nature of PitNETs Using Serological Markers in Combination with Imaging Biomarkers

• 摘要：垂体神经内分泌肿瘤(PitNETs)具有高度异质性,其侵袭性特征和复杂的临床表现为早期诊断和治疗带来了挑战。侵袭性诊断通常依赖于术后病理组织的确认,而血清学标志物和影像组学术前即可获得,且可以无创动态监测,同时影像特征能够有效反映肿瘤的生物学行为。近年来,随着生物医学技术的发展,血清学标志物IGF-1、GH、PRL、ACTH及TSH等与影像组学的结合为PitNETs的侵袭性预测开辟了新的研究领域。这种联合方法不仅提高了侵袭性预测的准确性,还为个体化治疗提供了新的思路。然而,目前在实际应用中仍存在一些技术挑战,包括标志物选择的标准化、影像数据处理的复杂性以及临床转化的可行性等问题。本文将全面回顾血清学标志物与影像组学在PitNETs侵袭性预测方面的最新研究进展,分析二者联合应用的潜在优势,探讨面临的技术挑战以及未来的发展趋势。通过系统整合现有研究成果,旨在为临床应用和后续的相关研究提供有价值的参考依据。

  关键词： 垂体神经内分泌肿瘤; Ki-67指数; 影像组学; 血清学标志物; 侵袭性预测

   

  Abstract: Pituitary neuroendocrine tumors (PitNETs) exhibit significant heterogeneity, and their aggressive characteristics and complex clinical manifestations pose challenges for early diagnosis and treatment. The aggressive diagnosis usually relies on the confirmation of postoperative pathological tissue, while serum markers and imaging can be obtained preoperatively and can be non-invasively monitored dynamically. At the same time, the imaging features can effectively reflect the biological behavior of the tumor. In recent years, with the development of biomedical technology, the combination of serological markers such as IGF-1, GH, PRL, ACTH, and TSH with imaging cytology has opened up new research areas for the invasion prediction of PitNETs. This combined method not only improves the accuracy of invasion prediction, but also provides new ideas for individualized treatment. However, there are still some technical challenges in practical application, including the standardization of marker selection, the complexity of image data processing, and the feasibility of clinical transformation. This article will comprehensively review the latest research progress of serological markers and imaging genomics in the invasion prediction of PitNETs, analyze the potential advantages of their joint application, explore the technical challenges faced, and discuss the future development trends. By systematically integrating the existing research results, it aims to provide valuable reference for clinical application and subsequent related research.

  Key words: pituitary neuroendocrine tumor; Ki-67 index; imaging; serological markers; invasive prediction

  提交时间：2025-08-18

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  2	2025-06-15	bmr.202508.00037V2	下载
  1	2025-06-16	bmr.202508.00037V1	下载

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