通讯作者: 王忠, 2775512142@qq.com

DOI：10.12201/bmr.202501.00060

Plasma C1q/ tumor necrosis factor-associated protein 6 and systemic inflammatory response index levels in patients with heart failure and their clinical significance

• 摘要：目的 探究心力衰竭(heart failure, HF)患者血浆C1q/肿瘤坏死因子相关蛋白6(complement C1q/tumor necrosis factor-related protein 6, CTRP6)及系统性炎症反应指数(systemic inflammation response index, SIRI)水平及临床意义。方法 选取2023年10月至2024年9月于石河子大学第一附属医院心脏中心住院的HF患者126例,根据LVEF值分为HFrEF组(n=43)、HFmrEF组(n=45)、HFpEF组(n=38)；以及同期就诊的38例非HF患者作为对照组。收集血常规、NT-proBNP、超声心动图参数,计算SIRI和左室质量指数(left ventricular mass index, IVMI),采用酶联免疫吸附法检测血浆CTRP6水平,分析HF患者CTRP6、SIRI与LVEF、IVMI、NT-proBNP、NYHA分级的相关性,logistic回归分析法分析HF的危险因素,绘制ROC曲线。结果 与对照组相比,HF患者的Cr、UA、eGFR、SIRI水平升高,合并冠心病、房颤史的比例升高,CTRP6水平降低,差异具有统计学意义(P＜0.05)；不同射血分数分型心力衰竭患者的CTRP6、NT-proBNP、LVEF、IVMI具有统计学差异(P＜0.05)；Spearman相关性分析显示:HF患者的CTRP6水平与LVEF呈正相关,与LVMI呈负相关；SIRI与NT-proBNP呈正相关,与LVEF呈负相关。多因素回归分析显示:CTRP6降低、Cr升高及房颤史是心力衰竭的危险因素。绘制CTRP6、SIRI及二者联合诊断HF的ROC曲线下面积分别为0.762、0.772、0.850。结论 HF患者血浆CTRP6水平显著降低,SIRI显著升高,二者对HF均具有诊断价值,且二者联合检测可提高诊断效能。CTRP6随着心力衰竭程度的加重而降低,CTRP6可能是HF的新型生物标志物。

  关键词： C1q/肿瘤坏死因子相关蛋白6; 系统性炎症反应指数; 心力衰竭; 左心室重构; 左心室射血分数; 左室质量指数

   

  Abstract: Objective To investigate the plasma levels of C1q/ tumor necrosis factor-associated protein 6(CTRP6) and systemic inflammatory response index (SIRI) in patients with heart failure (HF) and their clinical significance. Methods 126 HF patients admitted to the Heart Center of the First Affiliated Hospital of Shihezi University from October 2023 to September 2024 were selected and divided into HFrEF group (n=43), HFmrEF group (n=45) and HFpEF group (n=38) according to LVEF value. And 38 non-HF patients treated in the same period were used as control group. Blood routine, NT-proBNP and echocardiogram parameters were collected, SIRI and left ventricular mass index (IVMI) were calculated, plasma CTRP6 levels were detected by enzyme-linked immunosorbent assay, and the correlation between CTRP6, SIRI and LVEF, IVMI, NT-proBNP and NYHA grades in HF patients was analyzed. Risk factors of HF were analyzed by logistic regression analysis and ROC curve was drawn. Results Compared with the control group, the levels of Cr, UA, eGFR and SIRI in HF patients were increased, the proportion of patients with history of coronary heart disease and atrial fibrillation was increased, and CTRP6 level was decreased, the difference was statistically significant (P < 0.05). There were statistical differences in CTRP6, NT-proBNP, LVEF and IVMI of patients with different ejection fraction classification (P < 0.05). Spearman correlation analysis showed that CTRP6 level was positively correlated with LVEF and negatively correlated with LVMI in HF patients. SIRI was positively correlated with NT-proBNP and negatively correlated with LVEF. Multivariate regression analysis showed that lower CTRP6, higher Cr and history of atrial fibrillation were risk factors for different ejection fraction types of heart failure. The area under ROC curve of CTRP6, SIRI and their combined diagnosis HF are 0.762, 0.772 and 0.850, respectively. Conclusion The plasma CTRP6 level in HF patients is significantly decreased, and SIRI is significantly increased. Both of them have diagnostic value for HF patients, and their combined detection can improve the diagnostic efficiency. CTRP6 decreases with the severity of heart failure and may be a novel biomarker for HF.

  Key words: Complement C1q/tumor necrosis factor-related protein 6; Systemic inflammation response index; Heart failure; Left ventricle remodel; Left ventricular ejection fraction; Left ventricular mass index

  提交时间：2025-01-21

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• 序号	提交日期	编号	操作
  1	2025-01-08	bmr.202501.00060V1	下载

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