通讯作者: 蔡小继, 18704634467@163.com

DOI：10.12201/bmr.202502.00011

Analysis of the Distribution of High-risk Human Papillomavirus Subtypes and High-risk Factors among Women in Jiaxing, Zhejiang Province

• 摘要：【】:目的 调查本地区感染高危型人乳头瘤病毒(HR-HPV)亚型的分布情况及危险因素,为高危人群宫颈癌筛查提供参考。方法 选取浙江省宫颈癌检查项目管理系统中22573例女性进行HR-HPV筛查,分为HR-HPV阳性组2045例和阴性组20528例,分析患者的病史资料,对可能造成HR-HPV感染的因素进行单因素和多因素的回归分析。结果 人群中HR-HPV感染率为9%,HPV52型在单一感染中占首位(29.6%),多重感染中以2型感染率最高(13%)。HR-HPV阳性组与阴性组在年龄、文化程度、孕次、流产次数及不同街道方面差异有统计学意义(P＜0.05)。多因素Logistic回归分析显示,年龄>45岁,小学以上学历,孕2次是HR-HPV感染的独立危险因素。结论:HPV52型是本地区HR-HPV的优势型别,年龄>45岁,小学以上学历,孕2次是HR-HPV感染的相关危险因素,对人群的重点筛查,在宫颈病变的预防及治疗中有着举足轻重的作用。

  关键词： Analysis of the Distribution of High-risk Human Papillomavirus Subtypes and High-risk Factors among Women in Jiaxing, Zhejiang Province; ; ; ; 

   

  Abstract: Objective To investigate the distribution of high-risk human papillomavirus (HR-HPV) subtypes and risk factors in local area, so as to provide reference for cervical cancer screening in high-risk population. Methods A total of 22573 women from Zhejiang Cervical Cancer screening project management system were selected for HR-HPV screening, and they were divided into HR-HPV positive group (2045 cases) and negative group (20528 cases). The medical history data of the patients were analyzed, and the risk factors of HR-HPV infection were analyzed by univariate and multivariate regression analysis. Results The overall HR-HPV infection rate was 9%. HPV52 was the most common type in single infection (29.6%), and HPV2 was the most common type in multiple infections (13%). There were significant differences between HR-HPV positive group and negative group in age, education level, gravidity, number of abortions and different neighborhoods (P < 0.05). Multivariate Logistic regression analysis showed that age >45 years old, primary school education or above, twice pregnancy were independent risk factors for HR-HPV infection. Conclusions: HPV52 is the predominant type of HR-HPV in the local area. Age >45 years, education level above primary school, and twice pregnancy are related risk factors for HR-HPV infection.

  Key words: High-risk human papillomavirus (HR-HPV); Screening; Age; Education background; Risk Factors

  提交时间：2025-02-10

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• 序号	提交日期	编号	操作
  1	2024-12-30	bmr.202502.00011V1	下载

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