通讯作者: 邵旭华, Gjy1029413@126.com

DOI：10.12201/bmr.202501.00050

Correlation between t-P1NP/β-CTX and curative effect of Bushen Zhuanggu Decoction in patients with knee osteoarthritis

• 摘要：目的 探讨总I型胶原氨基酸延长肽（t-P1NP）/β胶原交联C端肽（β-CTX）与膝骨关节炎（KOA）患者补肾壮骨汤疗效的相关性。方法 选取2021年6月~2024年4月杭州市临平区中医院骨科诊治的120例肝肾亏虚型KOA患者，按随机数表法分为2组。对照组给予依托考昔片和奥美拉唑肠溶胶囊口服治疗，研究组在此基础上给予补肾壮骨汤方口服治疗，均持续治疗1个月。比较两组临床疗效和治疗前后中医证候积分、血清t-P1NP、β-CTX水平、t-P1NP/β-CTX比值、西安大略和麦克马斯特大学骨关节炎指数（WOMAC）评分及治疗期间不良反应发生率。结果 研究组总有效率为91.67%，显著高于对照组的78.33%（P＜0.05）；治疗后，与对照组比，研究组关节隐隐作痛、腰膝无力和腰膝酸软不适积分均显著降低（P＜0.05）；研究组t-P1NP、β-CTX水平低于对照组，t-P1NP/β-CTX比值高于对照组（P＜0.05）；研究组骨关节炎疼痛、僵硬和躯体功能损失等维度WOMAC评分均低于对照组（P＜0.05）；两组不良反应发生率无显著差异（P＞0.05）。结论 补肾壮骨汤可提高肝肾亏虚型KOA临床疗效，缓解中医证候和疼痛反应，提高t-P1NP/β-CTX比值，不良反应发生率低。

  关键词： 膝骨关节炎；补肾壮骨汤；治疗效果；总I型胶原氨基酸延长肽；β胶原交联C端肽; ; ; ; 

   

  Abstract: Objective To explore the correlation between total procollagen type 1 N-terminal propeptide (t-P1NP)/βcross-linked C-telopeptide of type 1 collagen (β-CTX) and curative effect of Bushen Zhuanggu Decoction in patients with knee osteoarthritis (KOA). Methods A total of 120 patients with KOA of liver-kidney deficiency type in Orthopedics Department of Linping District Hospital of Traditional Chinese Medicine, Hangzhou, were enrolled between June 2021 and April 2024. According to random number table method, they were divided into control group (oral etocoxib tablets and omeprazole enteric-coated capsules) and study group (Bushen Zhuanggu Decoction on basis of control group). All patients were treated for 1 month. The clinical curative effect, scores of TCM syndromes, levels of serum t-P1NP and β-CTX, t-P1NP/β-CTX and scores of the western ontario and mcmaster universities (WOMAC) before and after treatment, and the incidence of adverse reactions during treatment were compared between the two groups. Results The total response rate of study group was significantly higher than that of control group (91.67% vs 78.33%, P<0.05). After treatment, scores of TCM syndromes (dull joint pain, waist-leg weakness, soreness and weakness of waist and knees) in study group were significantly lower than those in control group (P<0.05). The levels of t-P1NP and β-CTX in study group were lower than those in control group, while t-P1NP/β-CTX was greater than that in control group (P<0.05). The scores of WOMAC (osteoarthritis pain, stiffness, defects of physical function) in study group were lower than those in control group (P<0.05). The difference in the incidence of adverse reactions between the two groups was not statistically significant (P>0.05). Conclusion Bushen Zhuanggu Decoction can improve clinical curative effect, relieve TCM syndromes and pain response, increase t-P1NP/β-CTX and reduce incidence of adverse reactions in patients with KOA of liver-kidney deficiency type.

  Key words: Knee osteoarthritis; Bushen Zhuanggu Decoction; Curative effect; Total procollagen type 1 N-terminal propeptide; βcross-linked C-telopeptide of type 1 collagen

  提交时间：2025-01-18

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
• html

• 图表

• 魏贤振, 王海云, 丁以山, 陈朝蔚. 电针手法治疗膝骨关节炎的临床疗效-价值分析. 2024. doi: 10.12201/bmr.202412.00030

  张苗苗, 张丽娟, 郑玉兰, 田晨, 葛龙, 强群. 超声和MRI对膝骨关节炎诊断价值的Meta分析. 2024. doi: 10.12201/bmr.202412.00072

  陈家祈, 王丽, 朴春丽. 玉液汤联合二甲双胍治疗2型糖尿病Meta分析. 2024. doi: 10.12201/bmr.202407.00066

  张丽霞, 郎泽高, 王辉. PD患者SIRT1/NF-κB信号通路与认知功能损害的相关性. 2024. doi: 10.12201/bmr.202412.00077

  叶贝, 刘顺林. CPNE1、ZWILCH在肺腺癌演进中的表达及与预后的相关性分析. 2024. doi: 10.12201/bmr.202406.00030

  李森强, 冯琦, 宋才渊, 李伦辛. 张氏清热消瘀汤联合VSD治疗胫腓骨开放性骨折创面感染疗效及安全性. 2024. doi: 10.12201/bmr.202410.00023

  杨庆松, 张燕洁, 刘燕, 刘振. 加味散偏汤治疗肝郁血瘀型紧张型头痛临床观察. 2024. doi: 10.12201/bmr.202412.00019

  袁胜超, 谭志超, 李征, 林馥纯, 吴云飞. 四柱理念治疗SchatzkerⅠ-Ⅳ型胫骨平台骨折的临床疗效观察. 2024. doi: 10.12201/bmr.202411.00018

  马家慧, 王忠. 心力衰竭患者血浆C1q/肿瘤坏死因子相关蛋白6、系统性炎症反应指数水平及临床意义. 2025. doi: 10.12201/bmr.202501.00060

  李玉洁, 姚炎炎, 汤婧雯, 胡艳敏, 朱慎慎, 李琳琳, 吴照科. 联合炎症指标探讨类风湿性关节炎患者并发心血管疾病的危险因素. 2025. doi: 10.12201/bmr.202501.00044

• 序号	提交日期	编号	操作
  1	2024-11-27	bmr.202501.00050V1	下载

• 公开评论  匿名评论  仅发给作者 提交评论