通讯作者: 黄连江, 77592953@qq.com

DOI：10.12201/bmr.202412.00031

Non-lactation mastitis associated with Corynebacterium kroppenstedtii: a case report and literature reviewXIANG Yun, XIE Chunhong, SU Yuanhui, CHEN Xing, YANG Bing, NIE Yanqin, ZHANG Huiju, HUANG Lianjiang

• 摘要：非哺乳期乳腺炎是一类发生于非哺乳期的乳腺炎症，其病因复杂，可能与克氏棒状杆菌(克罗彭施泰特棒状杆菌,corynebacterium kroppenstedtii)有关，克氏棒状杆菌是一种亲脂性棒状杆菌，生长缓慢，在实验室中易漏诊。本文报道厦门市某医院2023年7月收治的1例克氏棒状杆菌所致非哺乳期乳腺炎患者，分析该患者的乳腺穿刺脓液标本的组织病理检查、一般细菌培养，运用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)对菌株进行鉴定，微量肉汤稀释法进行药敏试验。并结合相关文献复习。探讨克氏棒状杆菌所致非哺乳期乳腺炎的实验室诊断经验，为非哺乳期乳腺炎的规范诊疗提供一些参考。

  关键词： 非哺乳期乳腺炎; 亲脂性棒状杆菌; 克氏棒状杆菌; 基质辅助激光解吸电离飞行时间质谱

   

  Abstract: Objective: To investigate the laboratory diagnosis and provide some references for clinical treatment of non-lactation mastitis caused by Corynebacterium kroppenstedtii. Methods: Histopathological examination, general bacterial culture of breast aspiration ?uid samples from a patient with non-lactating mastitis caused by Corynebacterium kroppenstedtii admitted to a hospital in Xiamen in July 2023, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) to identify the isolates. Microdilution broth method was used to test their antimicrobial susceptibility. And literature review. Results: The patient was diagnosed as non-lactation mastitis caused by Corynebacterium kroppenstedtii through histopathological examination of breast aspiration ?uid samples and identification of cultured bacteria by mass spectrometry. According to the results of drug sensitivity test, the tumor was significantly reduced and the inflammation was improved after anti-infection by cefmetazole and anti-inflammatory by hormone treatment, and discharged. Conclusion: The reason for non-lactation mastitis is unclear, Corynebacterium kroppenstedtii, on account of the lipophilic nature and grow slowly, it is easy to escape diagnosis in the laboratory. Therefore, the microscopic examination for smear of Pus specimen staining should be done along with culturing of the bacteria, the culture conditions should be optimized, the culture time should be extended appropriately, and reliable techniques such as MALDI-TOF MS should be used to identify the bacteria. According to the results of drug sensitivity test, appropriate lipophilic antibiotics should be selected for treatment.

  Key words: Non-lactation mastitis; Lipophilic Corynebacterium; Corynebacterium kroppenstedtii; Matrix-assisted laser desorption ionization time-of-flight mass spectrometry

  提交时间：2024-12-12

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• 序号	提交日期	编号	操作
  3	2024-11-14	bmr.202412.00031V3	下载
  2	2024-11-14	bmr.202412.00031V2	下载
  1	2024-11-14	bmr.202412.00031V1	下载

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