通讯作者: .吴作艳, wuzuoyan118@aliyun.com

DOI：10.12201/bmr.202411.00023

Evaluation of the efficacy of Linalotide combined with PEG in the bowel preparation for colonoscopy of patients with chronic constipation

• 摘要：目的 探究利那洛肽联合复方聚乙二醇电解质散（PEG）在慢性便秘患者结肠镜检查肠道准备中的的应用效果。 方法 选取 2023年1月至2023年10月在北京市第六医院行肠镜检查的慢性便秘患者190例，随机分为3L PEG组(肠道准备时服用 3L PEG)、利那洛肽组(肠道准备时服用利那洛肽联合3L PEG)和4L PEG 组(肠道准备时服用 4L PEG)。比较三组的应用效果。 结果 利那洛肽组的Boston肠道准备量表评分高于3L PEG 组和4L PEG组，组间比较有统计学差异（P＜0.05）。利那洛肽组患者的清肠合格率优于3L PEG组，组间比较有统计学差异（P＜0.05），两组患者重复肠道准备的意愿和不良反应发生率比较无统计学差异(P＞0.05)。利那洛肽组清肠合格率优于4L PEG组，组间差异有统计学意义（P＜0.05），不良反应发生率低于4L PEG组，重复肠道准备意愿高于4L PEG组，组间差异均具有统计学意义（P＜0.05）。4L PEG组清肠合格率优于3L PEG组，组间差异有统计学意义（P＜0.05），不良反应发生率高于3L PEG组，重复肠道准备意愿低于3L PEG组，差异均具有统计学意义（P＜0.05）。结论 利那洛肽联PEG可提高慢性便秘患者的结肠镜检查肠道准备质量，又不增加肠道准备时的不良反应，适合慢性便秘患者临床应用。

  关键词： 复方聚乙二醇电解质散; 利那洛肽; 便秘; 结肠镜检查; 肠道准备

   

  Abstract: ObjectiveTo explore the application of linaclotide combined with compound polyethylene glycol electrolyte powder ( PEG) in bowel preparation for colonoscopy of patients with chronic constipation. Methods A toltal of 190 patients with chronic constipation who enderwent electronic colonoscopy in Beijing Sixth Hospital from January to October 2023 were selected as the research objects.The patients were randomized to 3L PEG group (3L PEG), linaclotide group ( linaclotide combined with 3L PEG), and 4L PEG group (4L PEG).The application effects of the three groups were compared. Results The total score of Boston Bowel Preparation Scale(BBPS) in linaclotide group was higher than that in 3L PEG group and 4 PEG group ，and the difference was statistically significant(P＜0. 05) .The qualified rate of intestinal cleaning in linaclotide group was higher than that in 3L PEG group（P＜0.05）,and the incidence of adverse reactions and the willingness to repeat were no statistically significant difference between two groups(P＞0.05).The qualified rate of intestinal cleaning and the willingness to repeat in linaclotide group were higher than that in 4L PEG group（P＜0.05），and the incidence of adverse reactions was lower than that in 4 PEG group （P＜0.05）.The qualified rate of intestinal cleaning in 4L PEG group was higher than that in 3L PEG group（P＜0.05）,however, the incidence of adverse reactions was higher than in 3PEG group（P＜0.05）,and the willingness to repeat was lower than in 3PEG group(P＜0.05).Conclusion Linaclotide combined with PEG can not only improve the intestinal cleaning quality of patients with constipation, but also do not increase the adversereactions of patients, which is suitable for clinical application of patients with chronic constipation.

  Key words: linaclotide; PEG; bowel preparation; chronic constipation; 

  提交时间：2024-11-11

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• 序号	提交日期	编号	操作
  1	2024-08-29	bmr.202411.00023V1	下载

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