通讯作者: 李金娥, lijine2008@163.com

DOI：10.12201/bmr.202408.00052

Acute urethral obstruction caused by urinary tract infection induced by pegylated interferon alpha in the treatment of chronic hepatitis b: a case report

• 摘要：虽然干扰素相关的不良反应较常见,但发生尿路感染导致急性尿道梗阻的病例并不多见。本文回顾性分析既往收治的使用聚乙二醇干扰素a抗病毒治疗后发生尿路感染并导致急性尿道梗阻的慢性乙型肝炎患者1例,患者以高热、尿路刺激征及下腹痛、会阴区坠胀为主要表现,严重时有急性尿潴留的临床表现,完善尿液与血液相关检查以及影像学检查后诊断为尿路感染并急性尿道梗阻。经过停止干扰素治疗,及时给予抗感染及对症治疗后排尿功能恢复正常。在使用干扰素治疗过程中,对男性患者,尤其是老年或合并前列腺增大的患者,需密切监测药物不良反应,提前告知患者有发生尿路感染、甚至急性尿道梗阻的可能,要早发现,及时采取有效治疗措施,避免延误治疗。

  关键词： 慢性乙型肝炎; 干扰素; 尿路感染; 尿道梗阻

   

  Abstract: Although adverse reactions related to interferon are common, cases of urinary tract infection leading to acute urethral obstruction are rare. This article retrospectively analyzes a case of chronic hepatitis B patients who were treated with pegylated interferon alpha antiviral therapy and developed urinary tract infection leading to acute urethral obstruction. The patient presented with high fever, urinary irritation, lower abdominal pain, and perineal distension. In severe cases, there were clinical manifestations of acute urethral obstruction. After completing urine and blood-related examinations and imaging tests, it was diagnosed as urinary tract infection and acute urethral obstruction. After stopping interferon treatment and timely anti-infection and symptomatic treatment, the patients urination function returned to normal. During the treatment with interferon, male patients, especially elderly or patients with enlarged prostate, need to be closely monitored for adverse drug reactions. Patients should be informed in advance of the possibility of urinary tract infection and even acute urethral obstruction. Early detection and timely effective treatment measures should be taken to avoid delayed treatment.

  Key words: Chronic hepatitis B; Interferon; Urinary tract infection；Urethral obstruction; 

  提交时间：2024-08-26

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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