通讯作者: 刘传磊, cz_lchl@sina.com

DOI：10.12201/bmr.202409.00023

Clinical significance of detecting blood D-dimer and CEA levels before treatment in colorectal cancer patients

• 摘要：目的 研究治疗前血清CEA和D-二聚体的异常表达与结直肠癌临床病理资料的关系,并探讨其对结直肠癌复发转移及生存率的影响。方法 选取于2017年1月至2018年12月在我院首次诊断结直肠癌并行根治性手术的患者209例,检测治疗前血清D-二聚体和CEA水平,分析临床病理资料,并进行术后随访。结果 结直肠癌患者治疗前血D-二聚体和CEA阳性率均明显高于对照组(P< 0.001)。治疗前血D-二聚体和CEA与结直肠癌术后复发和总体生存等均相关(P<0.05)。治疗前血D-二聚体和CEA存在相关性(P<0.05)。治疗前血D-二聚体和CEA同时阳性是影响结直肠癌术后复发和生存的独立因素。治疗前D-二聚体和CEA同时阳性对总体生存期影响的ROC曲线下面积为0.723(P<0.001)。结论 治疗前D-二聚体和CEA对结直肠癌诊断和预后判断有重要价值。治疗前D-二聚体和CEA同时阳性对结直肠癌术后生存评估的准确性效果确切。联合检测有重要价值。且二者有相关性,对理解结直肠癌的行为提供思路。

  关键词： D-二聚体; CEA; 治疗前; 结直肠癌; 预后; ROC曲线

   

  Abstract: Objective To investigate the relationship between the abnormal expression of pre-treatment serum CEA and D-dimer and the clinicopathological data of colorectal cancer, and to explore they effect on the recurrence, metastasis and survival rate of colorectal cancer. Methods A total of 209 patients who were diagnosed with colorectal cancer for the first time in our hospital from January 2017 to December 2018 and underwent radical surgery were enrolled, and the serum levels of D-dimer and CEA before treatment were measured, the clinicopathological data were analyzed, and the postoperative follow-up was performed. Results The positive rates of D-dimer and CEA in colorectal cancer patients were significantly higher than those in the control group (P<0.001). Pre-treatment blood D-dimer and CEA were associated with recurrence and overall survival of colorectal cancer after surgery (P<0.05). There was a correlation between pre-treatment blood D-dimer and CEA (P<0.05). Positive pre-treatmentblood D-dimer and CEA are independent factors affecting the recurrence and survival of colorectal cancer after surgery. The area under the ROC curve of the effect of both positive pre-treatmentD-dimer and CEA on overall survival was 0.723 (P<0.001). Conclusion Pre-treatment D-dimer and CEA have important value in the diagnosis and prognosis of colorectal cancer. Both positive D-dimer and CEA before treatment had a definite effect on the accuracy of postoperative survival assessment of colorectal cancer. Co-testing is of great value. And the two are related, which provides ideas for understanding the behavior of colorectal cancer.

  Key words: D-dimer; CEA; Pre-treatment; Colorectal cancer; Prognosis; ROC curve

  提交时间：2024-09-13

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2024-08-11	bmr.202409.00023V1	下载

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