通讯作者: 徐茂晟, xms96cc@126.com

DOI：10.12201/bmr.202409.00010

The value of SWE in early liver and kidney fibrosis in MAFLD

• 摘要：目的 探索剪切波弹性成像（shear wave elastography, SWE）在评估代谢相关脂肪性肝病（metabolic associated fatty liver disease, MAFLD）人群早期肝脏及肾脏纤维化中的应用价值。方法 本研究共纳入92例患者，其中MAFLD患者52例，对照组40例。收集患者的一般资料，实验室检查资料和超声资料，比较两组间各项指标的差异性和相关性，评价SWE弹性值在MAFLD人群肝脏纤维化和肾脏纤维化中的应用价值。结果 MAFLD组肝功能指标及尿酸高于对照组。MAFLD组血小板比率指数(aspartate aminotransferase-to-platelet ratio index，APRI)高于对照组。FIB-4指数(fibrosis 4 score，FIB-4）、肌酐、尿素氮及肾小球滤过率估计值 (estimated glomerular filtration rate，eGFR)与对照组之间无显著差异。MAFLD组肝脏亮度、肝肾比及肝脏弹性值高于对照组。肾脏弹性值两组间无显著差异。肝脏弹性值与ALT具有一定的相关性。肝肾比与BMI、ALT、AST、ALP、γ-谷氨酰转肽酶和APRI具有一定的相关性。右肾皮质弹性值与其他指标间无显著相关性。结论 SWE有助于早期识别MAFLD人群中的肝脏硬度的变化。SWE在MAFLD人群早期肾脏纤维化中的应用价值有待进一步评估。

  关键词： 代谢相关脂肪性肝病; 剪切波弹性成像; 肝脏纤维化；肾脏纤维化

   

  Abstract: Objective To explore the value of shear wave elastography (SWE) in the early assessment of liver and kidney fibrosis in patients with metabolic associated fatty liver disease (MAFLD). Methods A total of 92 patients were included in this study, with 52 MAFLD patients and 40 controls. General information, laboratory data, and ultrasound data were collected and compared between the two groups. The differences between the two groups, as well as the correlations between the indicators, were compared. The value of SWE elastography in liver and kidney fibrosis in MAFLD population was assessed. Results Liver function indicators and uric acid were higher in the MAFLD group than in the control group. Aspartate aminotransferase-to-platelet ratio index (APRI) were higher in the MAFLD group than in the control group. There was no significant difference between the two groups in fibrosis 4 score (FIB-4), creatinine, blood urea nitrogen, and estimated glomerular filtration rate (eGFR). The brightness of the liver, liver-kidney ratio, and liver elasticity value were higher in the MAFLD group than in the control group. There was no significant difference in kidney elasticity values between the two groups. Liver elasticity values was correlated with alanine aminotransferase (ALT). The liver-kidney ratio was correlated with body mass index (BMI), ALT, aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase and APRI. There was no significant correlation between right renal cortex elasticity value and other indicators. Conclusion SWE helps in early identification of liver hardness in the MAFLD population. The application of SWE in early kidney fibrosis in the MAFLD population needs further evaluation.

  Key words: metabolic associated fatty liver disease; shear wave elastography; liver fibrosis；kidney fibrosis

  提交时间：2024-09-05

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• 序号	提交日期	编号	操作
  1	2024-07-14	bmr.202409.00010V1	下载

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