通讯作者: 石亚军, 5266255@qq.com

DOI：10.12201/bmr.202408.00024

• 摘要：【摘要】 目的 探索耐多药和利福平耐药肺结核病（Multidrug-resistant and rifampin-resistant pulmonary tuberculosis，MDR/RR-PTB）患者的健康相关生命质量（Health related quality of life，HRQOL），并分析其影响因素。方法 收集巴中市2021-2024年在《结核病管理信息系统》中登记治疗管理的50例MDR/RR-PTB患者（耐药组），采用1：1配对病例对照研究，选取在这期间在该系统登记治疗管理的对抗结核药物治疗敏感的肺结核患者50例作为对照组，采用横断面调查方法，用肺结核患者生命质量测定量表（Quality of Life Instuments for Chronic Disease Pulmonary Tuberculosis,QLICD-PT）测量并比较两组HRQOL，用多重线性回归分析法分析影响MDR/RR-PTB患者HRQOL的因素。结果 MDR/RR-PTB组患者在治疗前生命质量总分、心理功能、社会功能、特异性模块、生理功能、分别为（123.06±16.67）分、（30.94±6.52）分、（26.06±4.70）分、（40.82±3.42）、（25.24±5.58）分，对照组得分分别为（134.56±12.91）分、（35.28±4.59）分、（27.94±3.20）分、（44.16±3.10）分、（27.18±4.97）分，除生理功能外，MDR/RR-PTB组与对照组在生命质量总分、心理功能、社会功能及特异性模块方面差异有统计学意义(t值分别为 3.858、3.848、2.337、5.116，P值<0.05）。单因素分析显示：不同性别、医保情况、家庭月收入情况、有无合并症、淋巴细胞计数、白蛋白、C反应蛋白、体重指数（BMI）的患者生活质量总分差异性存在统计学意义（P<0.05）。多重线性回归分析显示，患者的医保、家庭月收入情况偏回归系数检验的P值均 < 0.05，在α=0.05的检验水准下，有统计学显著性。结论 MDR/RR-PTB患者HRQOL低于抗结核药物敏感的肺结核患者，患者的医保、家庭月收入情况是MDR/RR-PTB患者HRQOL的可能影响因素。

  关键词： ; ; ; 

   

  Abstract: Abstract Objective: To explore the health-related quality of life (HRQOL) among patients with multidrug-resistant and rifampin-resistant pulmonary tuberculosis (MDR/RR-PTB) and analyze its influencing factors. Method: Data was collected from 50 MDR/RR-PTB patients registered for treatment management in the “Tuberculosis Management Information System” in Bazhong City from 2021 to 2024 (resistance group). A 1:1 matched case-control study was conducted, selecting 50 pulmonary tuberculosis patients sensitive to anti-tuberculosis drug treatment registered in the system during the same period as the control group. A cross-sectional survey method was employed using the Quality of Life Instruments for Chronic Disease Pulmonary Tuberculosis (QLICD-PT) to measure and compare the HRQOL between the two groups. Multiple linear regression analysis was used to analyze factors affecting the HRQOL of MDR/RR-PTB patients. Results: Before treatment, the total HRQOL score, psychological function, social function, specificity module, and physiological function of the MDR/RR-PTB group were (123.06±16.67), (30.94±6.52), (26.04±4.70), (40.82±3.42), and (25.24±5.58), respectively, while those of the control group were (134.56±12.91), (35.28±4.59), (27.94±3.20), (44.16±3.10), and (27.18±4.97), respectively. Except for physiological function,there was a statistically significant difference between the MDR/RR-PTB group and the control group in terms of total quality of life score, psychological function, social function, and specific modules (t values were 3.858, 3.848, 2.337, and 5.116 respectively, P value <0.05). Univariate analysis showed that there were statistically significant differences in the total quality of life scores among patients with different genders, medical insurance statuses, monthly family income situations, presence or absence of comorbidities, lymphocyte count, albumin, C-reactive protein , and body mass index (BMI) (P<0.05). Multiple linear regression analysis revealed that the P values for the partial regression coefficient tests of patients medical insurance and monthly family income situations were both < 0.05, indicating statistical significance at the α=0.05 level of significance. Conclusion: The HRQOL of MDR/RR-PTB patients is lower than that of pulmonary tuberculosis patients sensitive to anti-tuberculosis drugs. The patients health insurance and monthly family income are potential factors affecting the HRQOL of MDR/RR-PTB patients.

  Key words: Drug-resistant; pulmonary tuberculosis, Health, Quality; of life, Influencing; factors, Statistics

  提交时间：2024-08-13

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  1	2024-07-02	bmr.202408.00024V1	下载

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