Bidirectional Two-Sample Mendelian Randomization Study of the Causal Relationship Between Asthma-related Pneumonia and Heart Failure

Corresponding author: LIU Qingyan, 29372728@qq.com

DOI: 10.12201/bmr.202509.00016

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  Abstract: Objectives To explore the causal relationship between Asthma-related pneumonia and Heart failure (HF) by using bidirectional two-sample Mendelian randomization (MR) analysis. Methods This study systematically evaluated the causal relationship between asthma-related pneumonia and HF through a two-sample MR analysis based on publicly available genome-wide association study (GWAS) data, employing Inverse Variance Weighted (IVW), MR-Egger, weighted median, weighted mode, and simple mode methods. Sensitivity analyses using different models and testing approaches were conducted to assess the robustness of the results. Results According to the results of IVW analysis, there is a causal relationship between Asthma-related pneumonia and HF risk (OR=1.113, 95%CI: 1.027~1.206, P=0.009). On the other hand, HF was not found to have a causal effect on Asthma-related pneumonia risk based on IVW analysis (OR=1.018, 95%CI: 0.780~1.328, P=0.893). The IVs used in all MR analyses showed no heterogeneity or horizontal pleiotropy. Moreover, the leave-one-out analysis revealed that no single SNP disproportionately influenced the results, further confirming the credibility of the bidirectional MR findings. Conclusion Through this study, it has been established that there is a causal relationship between pneumonia related to Asthma and the risk of HF. However, no definitive causal link has been found from HF to Asthma-related pneumonia. These insightful findings provide guidance for effectively managing the health of Asthma-related pneumonia with HF.

  Key words: Pneumonia related to Asthma; Heart failure; Mendelian randomization (MR) analysis; Causal relationship

  Submit time: 3 September 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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