A Mendelian randomization study on the causal relationship between 25-hydroxyvitamin D and tic disorder

Corresponding author: Jiang Chunming, cm_jiang@126.com

DOI: 10.12201/bmr.202507.00007

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  Abstract: Objective To explore the causal relationship between 25-hydroxyvitamin D 25(OH)D and tic disorder (TD). Methods A two sample Mendelian randomization (TSMR) analysis was conducted to explore the causal relationship between 25(OH)D and TD. Single nucleotide polymorphisms (SNP) associated with exposure and outcome were selected from the genome-wide association studies (GWAS) datasets of the publicly gene databases.25(OH)D was taken as the exposure, its single nucleotide polymorphism (SNP) as instrumental variables, and TD as the outcome variable. Causal inferences were made through inverse variance weighted (IVW).Data analysis and visualization were processed by Rstudio software. Results In the forward Mendelian randomization (MR) analysis, 75 SNPs of 25(OH) D were included. The effect evaluation results of the IVW method showed that the influence of 25(OH)D on TD was not statistically significant (P=0.3427). In addition, neither the MR-Egger method (P=0.9170), WM method(P=0.6378) , nor the WME(P=0.3445) found that the influence of 25(OH)D on TD was statistically significant. Reverse MR analysis included 5 SNPs of TD, and the effect evaluation results of IVW method showed that TD had no statistically significant effect on 25 (OH) D (P=0.1257). In addition, the results of MR-Egger method (P=0.2371), WM method (P=0.1091), and WME method (P=0.1870) all showed no causal relationship between TD and 25 (OH) D(P>0.05). Conclusion Don’t find a causal relationship between 25(OH)D and TD.

  Key words: 25(OH)D; TD; Mendelian randomization; Causal relationship; Finngen

  Submit time: 3 July 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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