Progress in the Mechanisms and Treatment of Oxaliplatin-Induced Acute Peripheral Neurotoxicity

Corresponding author: DING Rong, 19862728400@163.com

DOI: 10.12201/bmr.202506.00065

•  

  Abstract: Oxaliplatin-induced peripheral neuropathy (OIPN) is a sensory nerve disorder characterized by peripheral neuritis, with its pathogenesis still not fully understood. Compared to chronic neurotoxicity, there has been relatively less research on acute OIPN. Western medicine primarily uses drugs such as duloxetine, antioxidants, and monosialotetrahexosylganglioside (GM1) for treatment. In traditional Chinese medicine, methods mainly include oral and external therapies with herbal medicine. Preliminary preclinical studies have achieved some results, but extensive and rigorous clinical trials are necessary for validation. Therefore, further investigation into the mechanisms underlying the onset and development of acute OIPN and summarizing treatment strategies are of significant importance.

  Key words: Oxaliplatin; Acute; Peripheral neuropathy; Treatment

  Submit time: 24 June 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
• html

• 图表

• zhaochengyu. Research Progress on the Relationship between Hyperuricemia and Diabetic Peripheral Neuropathy. 2024. doi: 10.12201/bmr.202408.00019

  chenyijun. . 2025. doi: 10.12201/bmr.202503.00082

  zhou bin. Acute urethral obstruction caused by urinary tract infection induced by pegylated interferon alpha in the treatment of chronic hepatitis b: a case report. 2024. doi: 10.12201/bmr.202408.00052

  zhuliang, lisha, chenqiaoqiao. The efficacy of glutamine dipeptide combined with octreotide on patients with acute pancreatitis related lung injury and its impacts on serum TLR4 and MMP-9 levels. 2024. doi: 10.12201/bmr.202412.00062

  Liu Yanan, Zhan Ming, Han Fei. Research Progress and Prospects of Finerenone in the Treatment of Diabetic Nephropathy. 2024. doi: 10.12201/bmr.202410.00033

  WuJie, Zhou Zhen-gan, XiaMing, SUN Hong-jie, Zhou Kai, Zhang Ting-rong, Li Shao-shan. Advancements in Surgical Treatment Research for Pituitary Neuroendocrine Tumors. 2025. doi: 10.12201/bmr.202501.00074

  A Study on the Prediction of Acute Coronary Syndrome Based on Coronary Fat Attenuation Index and Laboratory Indicators. 2024. doi: 10.12201/bmr.202409.00001

  LiuYong. Pathophysiological mechanism and diagnostic progress of perioperative acute kidney injury in cardiac surgeryHan Dong 1, Liu Yong2. 2024. doi: 10.12201/bmr.202410.00069

  Houyu, Liyong, Zhouweixing, Liyaozaho, Lili. Progress in the study of cryoablation-induced immune effects and combined immunotherapy. 2025. doi: 10.12201/bmr.202503.00061

  wuwan, liuzhenzhong, zhaolijuan, penweixian. Exploring the Application Value of Sini Decoction in Treating Sepsis Based on the Theory of Acute Deficiency Syndrome. 2025. doi: 10.12201/bmr.202507.00012

• ID	Submit time	Number	Download
  1	2025-05-26	bmr.202506.00065V1	Download

• Public  Anonymous  To author only Submit Comments