Research Progress of Granulocyte Colony Stimulating Factor in the Treatment of Liver Failure

Corresponding author: Zhaoxiaofang, 1105320747@qq.com

DOI: 10.12201/bmr.202505.00003

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  Abstract: Liver failure is a high-risk and high-mortality disease, and its pathogenesis is not yet fully understood. As an important cytokine, granulocyte-colony stimulating factor (G-CSF) has an important role in the clinical treatment of liver failure. The aim of this review is to summarize and analyze the research progress in recent years on the mechanism of G-CSFs role in liver failure, including its effects on hepatocyte regeneration, immunomodulation, survival improvement, and safety of clinical use.

  Key words: Granulocyte colony-stimulating factor; Liver failure; Hepatocyte regeneration; Regulation of immunity

  Submit time: 9 May 2025

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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