The Distribution of Pathogens and Antibiotic Resistance in Necrotizing Fasciitis in the Central Minority Areas of Guangxi

Corresponding author: Shou jia-bao, shoujiabao208@sina.com

DOI: 10.12201/bmr.202412.00045

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  Abstract: Objective: To summarize the pathogen distribution and antimicrobial susceptibility characteristics of necrotizing fasciitis in the ethnic minority areas of central Guangxi, providing evidence for early clinical anti-infection treatment.Methods: A retrospective analysis was conducted on microbial culture and antibiotic susceptibility test results from 69 necrotizing fasciitis cases treated in the Department of Trauma Repair and Burn Plastic Surgery at Liuzhou Workers Hospital from January 2017 to December 2023.Results: A total of 77 bacterial strains were isolated from 69 cases, including 24 Gram-positive bacteria, 48 Gram-negative bacteria, and 5 fungi. Single microorganism infections predominated, accounting for 66.07%. The predominant Gram-positive bacteria were Staphylococcus aureus (10 cases, 12.99%) and Streptococcus pyogenes (5 cases, 6.49%), while the primary Gram-negative bacteria were Klebsiella pneumoniae (13 cases, 16.88%) and Escherichia coli (10 cases, 12.99%). Multidrug-resistant (MDR) strains accounted for 10.39% (18 strains) of the total isolates. Gram-positive bacteria were more sensitive to vancomycin, linezolid, and tigecycline, while Gram-negative bacteria showed greater sensitivity to meropenem, cefoperazone, and ertapenem.Conclusion: In the ethnic minority areas of central Guangxi, Klebsiella pneumoniae is the most common pathogen causing necrotizing fasciitis. For initial anti-infection treatment, vancomycin combined with meropenem is recommended to maximize therapeutic effectiveness.

  Key words: necrotizing; fasciitis, pathogen; distribution, bacterial; drug resistance, pathogen; detection, antibiotics

  Submit time: 18 December 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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