Correlating White Matter Hyperintensities Severity with Collateral Disease Syndrome Type Distribution

Corresponding author: QIU Weiwen, weiwenq@hotmail.com

DOI: 10.12201/bmr.202411.00015

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  Abstract: 【Abstract】 Objective To explore the relationship between the severity of white matter hyperintensities (WMH) and the distribution of collateral disease syndrome types. Methods A cross-sectional study was conducted, including 208 patients with cerebral small vessel disease and white matter hyperintensities who met the criteria. All enrolled subjects in the study completed the collateral disease syndrome differentiation. WMH was graded on magnetic resonance imaging fluid-attenuated inversion recovery (FLAIR) sequences using the Fazekas scale and measured for volume. Results Among the 208 patients, there were 52 cases (25.00%) of the Brain Collateral Impoverishment (BCI) type, with a Fazekas score of 3 (2, 3), and WMH volume of (8.80±9.37) ml; 67 cases (32.21%) of the Brain Collateral Stasis (BCS) type, with a Fazekas score of 4 (3, 4), and WMH volume of (13.42±9.18) ml; 47 cases (22.60%) of the Brain Collateral Constraint (BCC) type, with a Fazekas score of 4 (3, 5), and WMH volume of (14.60±10.07) ml; and 42 cases (20.19%) of the Brain Collateral Occlusion (BCO) type, with a Fazekas score of 4 (4, 5), and WMH volume of (18.65±10.71) ml. Of these, 55 patients (26.44%) with a Fazekas score of 1-2 were most commonly of the BCI type, 105 patients (50.48%) with a score of 3-4 were most commonly of the BCS type, and 48 patients (23.08%) with a score of 5-6 were most commonly of the BCO type. There were statistically significant differences in Fazekas scores and WMH volumes between the BCI and BCO types and other syndrome types (P<0.05), but no significant differences were observed between the BCS and BCC types (P>0.05).Conclusion The severity of WMH corresponds to a certain distribution of collateral disease syndrome types, and can serve as a reference indicator for assessing the severity of illness in patients with collateral disease.

  Key words: collateral disease; syndrome differentiation; white matter hyperintensities; cerebral small vessel disease.

  Submit time: 8 November 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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