Inference of causality between tea intake and sleep duration

Corresponding author: zhaoaitao, zat15949419926@163.com

DOI: 10.12201/bmr.202408.00012

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  Abstract: Objective: To explore the causal relationship between tea intake and sleep duration. Methods: Genome-wide association study data of tea intake and sleep duration (GWAS) were used, and the Inverse Variance Weighting method was used. IVW), MR-Egger regression analysis (MR-Egger regression analysis) and Weighted Median Analysis (WMA) were used to carry out two-sample Mendelian Randomization, MR) to evaluate the causal relationship between tea intake and sleep duration, and then conduct sensitivity analysis, including horizontal pleiotropic analysis, Cochran Q test and leave one method to evaluate the reliability and stability of the results. Results: After strict quality control conditions and elimination of confounding factors, 30 single nucleotide polymorphisms (SNPs) closely related to tea intake were screened out as instrumental variable, IVs). IVW(OR = 1.0585, 95% CI: 1.10132 ~ 1.1059, P = 0.0108) showed that there was a close positive causal relationship between tea intake and sleep duration. Although the MR-Egger regression analysis and WMA results did not reach statistical significance, the direction of causality aligns entirely with that of IVW, providing support for the interpretation of the findings. In this study, through the analysis of MR-Egger intercept and Cochran Q test, it was found that horizontal pleiotropy and heterogeneity had no significant influence on the research results (P > 0.05). Conclusion: MR results show that there is a positive causal relationship between tea intake and sleep duration, that is, under certain circumstances, the sleep duration can be increased to some extent with the increase of tea intake.

  Key words: tea intake; leep duration; Mendel randomization; single nucleotide polymorphism

  Submit time: 7 August 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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