林坤山, 戢婷. 乌灵胶囊联合酒石酸唑吡坦片治疗失眠的疗效观察. 2025. biomedRxiv.202507.00024
乌灵胶囊联合酒石酸唑吡坦片治疗失眠的疗效观察
通讯作者: 戢婷, 978452310@qq.com
DOI:10.12201/bmr.202507.00024
Observation of the efficacy of Wuling capsule combined with zolpidem tartrate tablets in the treatment of insomnia
Corresponding author: jiting, 978452310@qq.com
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摘要:摘要目的:探究对比乌灵胶囊与酒石酸唑吡坦片联合用药在失眠患者治疗中的效果差异,对比分析联合用药方案与单一镇静催眠类药物干预在临床上的获益。方法:检索我院信息系统收集 2024年12月至2025年3月就诊我院门诊辩证为心肾不交的失眠患者的临床资料作为研究素材,根据治疗方法分为观察组和对照组,每组30例(观察组为乌灵胶囊联合酒石酸唑比坦治疗,对照组为单独采用酒石酸唑比坦治疗)。对两组患者治疗前后的睡眠质量测评指标(匹兹堡睡眠质量指数PSQI)、中医证候积分、失眠严重程度指数量表(ISI)以及心理健康评估维度(包含焦虑自评量表SAS和抑郁自评量表SDS)等观测指标展开对比研究。结果:经过2周的临床干预,相比与对照组,观察组在PSQI、中医症候积分、ISI、SAS、SDS等多项维度评估中,均呈现出更显著的症状改善趋势(P<0.05)。结论:与单独使用酒石酸唑吡坦片相比,乌灵胶囊联合酒石酸唑吡坦片治疗辩证为“心肾不交”的失眠患者疗效更好,PSQI评分更低,情绪改善更明显。
Abstract: Abstract Objective: To explore and compare the effect difference of Wuling Capsules and zolpidem tartrate tablets in the treatment of insomnia patients, and to compare and analyze the clinical benefits of the combined medication scheme and single sedative-hypnotic drugs intervention. Methods: the information system of our hospital was retrieved to collect the clinical data of insomnia patients with heart kidney disharmony in our hospital outpatient department from December 2024 to March 2025 as research materials. According to the treatment method, they were divided into observation group and control group, with 30 cases in each group (the observation group was treated with Wuling capsule combined with zolpidem tartrate, and the control group was treated with zolpidem tartrate alone). The observation indexes of sleep quality evaluation index (Pittsburgh sleep quality index PSQI), TCM syndrome score, insomnia severity index (ISI) and mental health evaluation dimension (including self rating Anxiety Scale SAS and self rating Depression Scale SDS) of the two groups before and after treatment were compared. Results: after 2 weeks of clinical intervention, compared with the control group, the observation group showed a more significant trend of symptom improvement in PSQI, TCM symptom score, ISI, SAS, SDS and other dimensions(P<0.05). Conclusion: compared with zolpidem tartrate tablets alone, Wuling capsule combined with zolpidem tartrate tablets has better curative effect in the treatment of insomnia patients with heart kidney disharmony, lower PSQI score and more obvious emotional improvement.
Key words: Insomnia; Wuling capsule; Zolpidem tartrate; Integrative medicine;Anxiety;Depression提交时间:2025-07-07
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序号 提交日期 编号 操作 1 2025-06-28 bmr.202507.00024V1
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