通讯作者: 刘文霞, liuwenxia1018@163.com

DOI：10.12201/bmr.202506.00081

The effect of inflammation on the outcome of assisted conception in patients with endometriosis

• 摘要：目的 探讨炎症指标是否对卵巢型子宫内膜异位症（ovarian endometriosis，OEM）患者的体外受精/卵胞浆内单精子注射（in vitro fertilization/intracytoplasmic sperm injection，IVF/ICSI）助孕结局产生影响。方法 选取2019年1月1日至2024年2月1日期间于郑州大学第三附属医院生殖中心行IVF/ICSI治疗的OEM女性，其中未手术组73例、手术组112例，探讨两组间炎症标志物是否有差异以及是否对助孕结局产生影响。结果 与未手术组相比，手术组的淋巴细胞（lymphocyte，L）计数较高、血小板与淋巴细胞比值（platelet–lymphocyte ratio，PLR）较低、糖类蛋白125（carbohydrate antigen 125，CA125）较低，差异有统计学意义（均P＞0.05）。校正混杂因素后，L计数、PLR、CA125对临床妊娠率、活产率的影响无统计学意义，两组间临床妊娠率、活产率无统计学差异。结论 与未手术组相比，手术组的L计数较高、PRL和CA125较低，但这些改变对OEM患者IVF/ICSI助孕的临床妊娠及活产结局没有显著影响。

  关键词： 子宫内膜异位症；炎症标志物；体外受精；单精子注射；临床妊娠；活产; ; ; ; ; 

   

  Abstract: Objective To investigate whether inflammatory indicators have an impact on IVF/ICSI fertility outcomes in their patients with ovarian endometriosis (Ovarian endometriosis (OEM) patients with IVF/ICSI assisted conception outcomes. Methods OEM women who underwent IVF/ICSI treatment at the Reproductive Centre of the Third Affiliated Hospital of Zhengzhou University between 1 January 2019 and 1 February 2024 were selected, including 73 cases in the non-surgical group and 112 cases in the surgical group, to investigate whether there was a difference in inflammatory markers between the two groups and whether it had an impact on the outcome of assisted conception. Results Compared with the OEM group, the surgical group had higher lymphocyte (L) counts, lower platelet-lymphocyte ratio (PLR), and lower carbohydrate antigen 125 (CA125) in the surgical group. The differences were statistically significant (all P>0.05). No statistically significant differences were observed in neutrophil (N) count, platelet (PLT) count, neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) between the two groups (all P<0.05). statistical differences (all P<0.05). After correcting for confounders, the effects of L count, PLR, and CA125 on clinical pregnancy rate and live birth rate were not statistically significant; no statistical differences were observed in clinical pregnancy rate and live birth rate between the two groups. Conclusion The surgical group had higher L counts and lower PRL and CA125 compared to the non-surgical group, but these changes did not significantly affect the clinical pregnancy and live birth outcomes of IVF/ICSI-assisted conception in OEM patients.

  Key words: endometriosis; inflammatory markers; in vitro fertilization; sperm injection; clinical pregnancy; live births

  提交时间：2025-06-27

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• 序号	提交日期	编号	操作
  1	2025-03-21	bmr.202506.00081V1	下载

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