通讯作者: 李立▲, qgyzlili@163.com

DOI：10.12201/bmr.202503.00061

Progress in the study of cryoablation-induced immune effects and combined immunotherapy

• 摘要：冷冻消融是一种微创的肿瘤治疗方法,适用于早期肿瘤患者以及无法通过手术切除的晚期肿瘤患者,冷冻消融除引起肿瘤组织坏死和细胞凋亡外,还可以促进肿瘤自身抗原释放到血液中,包括损伤相关分子模式(DAMP)和肿瘤特异性抗原,这些抗原激活宿主免疫系统以引发抗肿瘤免疫反应,这可能导致原发肿瘤消退。但这种远隔效应并不能有效的抑制转移瘤的生长。近年来,免疫治疗是肿瘤治疗的重要手段之一,可有效激活患者自身的免疫系统,由于肿瘤免疫微环境的复杂性、免疫相关不良事件以及影响免疫反应的机制多因素,免疫治疗单一疗法在某些临床应用中尚未显示出令人满意的疗效。本文主要综述了冷冻消融诱导的免疫效应及联合免疫治疗的研究进展。

  关键词： 冷冻消融; 免疫机制; 免疫治疗; 联合治疗

   

  Abstract: Cryoablation is a minimally invasive tumor therapy for patients with early-stage tumors as well as those with advanced tumors that cannot be surgically removed. In addition to causing necrosis and apoptosis of tumor tissues, cryoablation promotes the release of tumor self-antigens into the bloodstream, including damage-associated molecular patterns (DAMP) and tumor-specific antigens, which activate the host immune system to trigger an anti-tumor immune response, which may lead to primary tumor regression. However, this distant effect is not effective in inhibiting the growth of metastatic tumors. In recent years, immunotherapy is one of the most important means of tumor treatment, which can effectively activate the patients own immune system. Due to the complexity of the tumor immune microenvironment, immune-related adverse events, and the multifactorial mechanisms affecting the immune response, immunotherapeutic monotherapies have not yet demonstrated satisfactory efficacy in some clinical applications. This article reviews the progress of cryoablation-induced immune effects and combined immunotherapy.

  Key words: cryoablation; immune mechanism; immunotherapy; combination therapy

  提交时间：2025-03-20

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2025-02-18	bmr.202503.00061V1	下载

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