刘雨丹, 李慧芳, 李建春, 翟亚仙, 杨锦湄△, 沈云霞. 帕金森病患者嗅觉障碍影响因素的系统评价. 2025. biomedRxiv.202503.00057
帕金森病患者嗅觉障碍影响因素的系统评价
通讯作者: 杨锦湄△, 412067652@qq.com
DOI:10.12201/bmr.202503.00057
Systematic Review of Factors Influencing Olfactory Dysfunction in Patients with Parkinsons Disease
Corresponding author: Yang Jinmei, 412067652@qq.com
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摘要:目的 本研究旨在探究帕金森病患者嗅觉障碍发生的影响因素并做系统评价与Meta分析。方法 检索Sinomed、维普、知网、万方、Web of Science、PubMed、Cochrane图书馆、Embase和Medline数据库中关于帕金森病嗅觉障碍影响因素的文章,检索时限自建库至2024年11月30日。文献筛选、数据提取以及质量评估工作由两位研究人员分别独立完成。本研究运用Revman5.3软件,针对帕金森病患者嗅觉障碍的相关影响因素开展了Meta分析。结果 共有13项研究(总样本量2465例)被纳入,共计18项影响因素,总结为疾病核心特征与进展因素,个体背景与环境交互因素2个主题。Meta分析表明,年龄MD=1.01,95%CI(-0.46,2.49),P=0.18、吸烟OR=0.88,95%CI(0.57,1.37),P=0.57、便秘OR=1.22,95%CI(0.38,3.93),P=0.74并非影响帕金森病患者嗅觉障碍的因素。结论 帕金森嗅觉障碍影响因素多与非运动症状相关,针对非运动症状开展干预策略(如改善睡眠质量、补充维生素D、早期认知训练)可能为延缓嗅觉障碍进展提供新思路。
Abstract: Objective: This study aimed to systematically investigate the influencing factors of olfactory dysfunction in patients with Parkinsons disease (PD) and conduct a systematic review and meta-analysis.Methods: Articles on factors influencing olfactory dysfunction in PD were retrieved from databases including Sinomed, VIP, CNKI, Wanfang, Web of Science, PubMed, Cochrane Library, Embase, and Medline, with the search period spanning from database inception to November 30, 2024. Literature screening, data extraction, and quality assessment were independently performed by two researchers. RevMan 5.3 software was utilized to conduct a meta-analysis on factors associated with olfactory dysfunction in PD patients.Results: A total of 13 studies (2,465 participants) were included, identifying 18 influencing factors categorized into two themes: disease core characteristics and progression factors and individual background and environmental interaction factors. Meta-analysis revealed that age MD = 1.01, 95% CI (-0.46, 2.49), P = 0.18, smoking OR = 0.88, 95% CI (0.57, 1.37), P = 0.57, and constipation OR = 1.22, 95% CI (0.38, 3.93), P = 0.74 were not significant factors influencing olfactory dysfunction in PD patients.Conclusion: The influencing factors of olfactory dysfunction in PD are predominantly associated with non-motor symptoms. Intervention strategies targeting non-motor symptoms—such as improving sleep quality, vitamin D supplementation, and early cognitive training—may offer novel approaches to delay the progression of olfactory dysfunction.
Key words: Parkinsons Disease; Olfactory Dysfunction; Influencing Factors; Systematic Review提交时间:2025-03-19
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序号 提交日期 编号 操作 1 2025-02-17 bmr.202503.00057V1
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