通讯作者: 唐芳, 64550932@qq.com

DOI：10.12201/bmr.202503.00033

Causal relationship between 25-hydroxyvitamin D and ankylosing spondylitis: a two-way Mendelian randomization study

• 摘要：目的：探讨25羟基维生素D（25-hydroxyvitamin D,25（OH）D）与强直性脊柱炎（ankylosing spondylitis,AS）是否存在因果关系。方法：从全基因组关联研究（GWAS）提取25（OH）D与AS的遗传数据，反方差加权（Inverse-variance weighted,IVW）为准确的估计结果，MR-Egger回归法、加权中位数（Weighted median,WM）、简单模式（Simple mode）、加权模式（Weighted mode）进行补充，并进行敏感性分析验证。结果：25（OH）D对AS的IVW法结果存在因果关系（OR = 0.805，95% CI:0.686 ~ 0. 944，P = 0.008），Penalised weighted median（OR = 0.799，95% CI：0.678 ~0.940，P = 0.007）显示一致结果。AS对25（OH）D的IVW法结果为不存在因果关系（OR =1.019，95% CI:0.995 ~ 1.043，P = 0.110）。另外，MR-Egger截距、Cochran Q检验、“Leave - one - out”及MR - PRESSO分析不存在水平多效性与异质性。结论：25（OH）D浓度与AS的发病可能存在遗传因果关系，AS不能导致体内25（OH）D的浓度变化。

  关键词： 25羟基维生素D；强直性脊柱炎；孟德尔随机化；因果关系; ; ; 

   

  Abstract: To explore whether there is a causal relationship between 25-hydroxyvitamin D (25(OH)D) and AS.Methods:Extract genetic data related to 25(OH)D and AS from genome-wide association studies (GWAS). Employ inverse variance weighting (IVW) for accurate estimation results. Additionally, utilize the MR-Egger regression method, weighted median (WM), and both simple mode and weighted mode for model supplementation. Finally, conduct sensitivity analyses and verification.Results:There is a causal relationship between 25(OH)D levels and the results of the inverse variance weighted (IVW) method in AS, as indicated by an odds ratio (OR) of 0.805 (95% CI: 0.686 – 0.944, P = 0.008). Similarly, the penalised weighted median method yielded consistent results with an OR of 0.799 (95% CI: 0.678 – 0.940, P = 0.007). However, the IVW methods result for AS concerning 25(OH)D indicates no causal relationship, with an OR of 1.019 (95% CI: 0.995 – 1.043, P = 0.110). Furthermore, analyses using the MR-Egger intercept, Cochrans Q test, the Leave-one-out method, and MR-PRESSO revealed no evidence of horizontal pleiotropy or heterogeneity.Conclusion:There may be a genetic causal relationship between 25-hydroxyvitamin D (25(OH)D) concentration and the onset of AS. However, AS does not influence the concentration of 25(OH)D in the body.

  Key words: 25-hydroxyvitamin D; ankylosing spondylitis; Mendelian randomization; causality

  提交时间：2025-03-13

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• 序号	提交日期	编号	操作
  1	2025-03-04	bmr.202503.00033V1	下载

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