通讯作者: 赵爱桃, zat15949419926@163.com

DOI：10.12201/bmr.202408.00012

Inference of causality between tea intake and sleep duration

• 摘要：目的:探究茶摄入量与睡眠持续时间之间的因果关系。方法:使用茶摄入量以及睡眠持续时间的全基因组关联分析数据(Genome-Wide Association Study, GWAS),通过逆方差加权法(Inverse Variance Weighting, IVW)、MR-Egger回归分析(MR-Egger regression analysis)、加权中位数分析(Weighted Median Analysis,WMA)方法进行两样本孟德尔随机化方法(Mendelian Randomization, MR)来评估茶摄入量与睡眠持续时间之间的因果关系,然后进行敏感性分析,包括水平多效性分析,Cochran Q检验及“留一法”评估结果可靠性及稳定性。结果:在严格的质控条件以及排除混淆因素后,筛选到30个与茶摄入量密切相关的单核苷酸多态性位点(Single nucleotide polymorphism, SNPs)作为工具变量(instrumental variable, IVs)。IVW(OR=1.0585,95% CI:1.10132~1.1059,P=0.0108)结果认为茶摄入量与睡眠持续时间之间存在密切的正向因果关系,另外MR-Egger回归分析(OR = 1.0603,95% CI:0.9891~1.1367,P = 0.0985)、WMA(OR = 1.0886,95% CI:0.9051~1.3093,P = 0.3755)结果虽然没有统计学意义,但是因果关系的方向与IVW的方向完全一致,可辅助解释结果。在本研究中,通过MR-Egger截距和Cochran Q检验分析发现,水平多效性和异质性对研究结果的影响不显著(P ＞ 0.05)。结论:MR结果显示茶摄入量与睡眠持续时间显示正向因果关系,即在一定情况下,随着茶摄入量的增多可一定程度增加睡眠持续时间。

  关键词： 茶摄入量,睡眠持续时间,孟德尔随机化,单核苷酸多态性; ; ; 

   

  Abstract: Objective: To explore the causal relationship between tea intake and sleep duration. Methods: Genome-wide association study data of tea intake and sleep duration (GWAS) were used, and the Inverse Variance Weighting method was used. IVW), MR-Egger regression analysis (MR-Egger regression analysis) and Weighted Median Analysis (WMA) were used to carry out two-sample Mendelian Randomization, MR) to evaluate the causal relationship between tea intake and sleep duration, and then conduct sensitivity analysis, including horizontal pleiotropic analysis, Cochran Q test and leave one method to evaluate the reliability and stability of the results. Results: After strict quality control conditions and elimination of confounding factors, 30 single nucleotide polymorphisms (SNPs) closely related to tea intake were screened out as instrumental variable, IVs). IVW(OR = 1.0585, 95% CI: 1.10132 ~ 1.1059, P = 0.0108) showed that there was a close positive causal relationship between tea intake and sleep duration. Although the MR-Egger regression analysis and WMA results did not reach statistical significance, the direction of causality aligns entirely with that of IVW, providing support for the interpretation of the findings. In this study, through the analysis of MR-Egger intercept and Cochran Q test, it was found that horizontal pleiotropy and heterogeneity had no significant influence on the research results (P > 0.05). Conclusion: MR results show that there is a positive causal relationship between tea intake and sleep duration, that is, under certain circumstances, the sleep duration can be increased to some extent with the increase of tea intake.

  Key words: tea intake; leep duration; Mendel randomization; single nucleotide polymorphism

  提交时间：2024-08-07

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• 序号	提交日期	编号	操作
  1	2024-07-29	bmr.202408.00012V1	下载

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