通讯作者: 蓝清华, ly98752@163.com

DOI：10.12201/bmr.202505.00045

Clinical study of recombinant human granulocyte-macrophage colony-stimulating factor combined with bifidobacterium in treatment of oral mucositis after chemotherapy
Lan? Qinghua 1, Zeng Qingfang 1, Xiao Wei 2, Zhan Tao 1,Zhong Jianming 1, Qiu Liujin 1

• 摘要：目的：探讨重组人粒细胞-巨噬细胞集落刺激因子(rhGM-CSF)联合双歧杆菌治疗化疗后口腔黏膜炎的临床疗效。方法：选取2022.08~2024.12赣州市肿瘤医院收治的60例化疗后口腔黏膜炎分为观察组、对照组，n=30。对照组以rhGM-CSF含漱治疗，观察组增加双歧杆菌三联活菌片口服。治疗2周后评估两组患者的临床疗效、症状评分、炎症因子水平、口腔微生态指标、治疗安全性。结果：观察组总有效率高于对照组(P<0.05)。治疗后，观察组症状评分包括水肿、充血、溃疡及视觉模拟评分(VAS)均低于对照组(P<0.05)。治疗后，观察组炎症因子Toll样受体4(TLR4)、半乳糖凝集素-3(Galectin-3)、白介素-8(IL-8)均低于对照组(P<0.05)。治疗后，观察组口腔微生态菌群包括乳酸菌、双歧杆菌高于对照组，牙龈卟啉单胞菌、福赛坦氏菌低于对照组(P<0.05)。两组不良反应发生率无差异性(P>0.05)。结论：重组人粒细胞-巨噬细胞集落刺激因子联合双歧杆菌治疗化疗后口腔黏膜炎的临床疗效显著，可减轻患者的各项症状，抑制炎症因子的表达，改善患者的口腔微生态，且治疗安全性良好。

  关键词： 化疗；口腔黏膜炎；双歧杆菌；重组人粒细胞-巨噬细胞集落刺激因子；临床疗效；口腔微生态; ; ; ; ; 

   

  Abstract: Objective: To investigate the clinical efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) combined with bifidobacterium in the treatment of oral mucositis after chemotherapy. Methods: 60 patients with oral mucositis after chemotherapy treated in Ganzhou Cancer Hospital from 2022.08 to 2024.12 were selected and divided into group observation and group control, n=30. The group control was gargled with rhGM-CSF, and the observation group was orally supplemented with bifidobacterium triplex viable tablets. After 2 weeks of treatment, the clinical efficacy, symptom score, inflammatory factor level, oral microecological index and treatment safety were evaluated. Results: The group observation total effective rate was higher than group control (P<0.05). Group observation symptom scores including edema, congestion, ulcer and visual analogue scale (VAS) were lower than group control (P<0.05). The group observation inflammatory factors toll-like receptor 4(TLR4), Galectin-3 (Galectin-3) and interleukin-8 (IL-8) were lower than group control (P<0.05). the oral microflora including Lactobacillus and bifidobacterium in observation group were higher than those in control group, while porphyromonas gingivalis and Forsetanella were lower than group control (P<0.05). There difference was no incidence of adverse reactions between the two groups (P>0.05). Conclusion: Recombinant human granulocyte-macrophage colony-stimulating factor combined with bifidobacterium has significant clinical efficacy in the treatment of oral mucositis after chemotherapy, which can reduce the symptoms of patients, inhibit the expression of inflammatory factors, improve the oral microecological, and the treatment is safe.

  Key words: chemotherapy; Oral mucositis; Bifidobacterium; Recombinant human granulocyte-macrophage colony-stimulating factor; Clinical effect; Oral microecology

  提交时间：2025-05-29

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• 序号	提交日期	编号	操作
  1	2025-04-20	bmr.202505.00045V1	下载

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