通讯作者: 雷后兴, zjleihx@163.com

DOI：10.12201/bmr.202504.00021

Clinical study on the treatment of chronic sinusitis in children by nasal irrigation with Melastoma dodecandrum Lour

• 摘要：目的 观察畲药地稔鼻腔冲洗治疗儿童慢性鼻窦炎的临床疗效、鼻窦CT Lund—Mackay评分、鼻腔冲洗液IL- 6、IL-8、TNF-α水平变化及安全性。方法 选择2022年1月至2022年6月我院门诊收治的63例慢性鼻窦炎患儿，随机分为对照组（n=33）与治疗组（n=30）。对照组采用2.3%高渗生理盐水鼻腔冲洗，治疗组采用畲药地稔鼻腔冲洗液进行鼻腔冲洗。比较两组患儿的临床疗效、鼻窦CT Lund—Mackay评分、鼻腔冲洗液IL-6、IL-8、TNF-α水平及安全性。结果 经过三个月的治疗，治疗组的整体有效率显著高于对照组（P＜0.05）。鼻窦CT Lund—Mackay评分显示，治疗后两组的评分均有所下降，其中治疗组的表现优于对照组（P＜0.05）。此外，两组患儿的鼻腔冲洗液中IL-6、IL-8及TNF-α水平相较于治疗前均有显著降低（P＜0.05），且治疗组在IL-6、IL-8的降低水平上比对照组更为显著（P＜0.05）。然而，在TNF-α的降低水平上，两组之间没有显著差异。在不良反应方面，两组相当，无统计学差异（P＞0.05）。结论 畲药地稔鼻腔冲洗可有效治疗儿童慢性鼻窦炎，临床总有效率、IL-6、IL-8炎症因子及鼻窦CT评分改善情况优于2.3%高渗生理海水，且安全性良好。

  关键词： 地稔；鼻腔冲洗；慢性鼻窦炎；儿童；临床研究; ; ; ; 

   

  Abstract: Objective To observe the clinical efficacy, CT Lund-mackay scores, levels of IL-6, IL-8, TNF-α and safety of MD nasal irrigation in the treatment of chronic sinusitis in children. Methods 63 children with chronic sinusitis admitted to our hospital from January 2022 to June 2022 were randomly divided into a control group (n=33) and a treatment group (n=30).. The control group was rinsed with 2.3% hypertonic saline, and the treatment group was rinsed with MD nasal rinsing solution. The clinical efficacy, sinus CT Lund-mackay scores, levels of IL-6, IL-8, TNF-α and safety of the nasal flush solution were compared between the two groups. Results After three months of treatment, the overall effective rate of the treatment group was significantly higher than that of the control group (P < 0.05). Sinus CT Lund-mackay scores showed that the scores of both groups decreased after treatment, and the performance of the treatment group was better than that of the control group (P < 0.05). In addition, the levels of IL-6, IL-8 and TNF-α in the nasal rinse solution of the two groups were significantly decreased compared with those before treatment (P < 0.05), and the reduction levels of IL-6 and IL-8 in the treatment group were more significant than those in the control group (P < 0.05). However, there was no significant difference between the two groups in terms of reduced levels of TNF-α. In terms of adverse reactions, there was no significant difference between the two groups (P > 0.05). Conclusion MD nasal irrigation can effectively treat chronic sinusitis in children, the clinical total effective rate, IL-6, IL-8 inflammatory factors and sinus CT score improvement are better than 2.3% hypertonic physiological seawater, and safety is good.

  Key words: Melastoma dodecandrum Lour; Nasal irrigation; Chronic sinusitis; Children; Clinical research

  提交时间：2025-04-08

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• 序号	提交日期	编号	操作
  1	2025-02-07	bmr.202504.00021V1	下载

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