通讯作者: 陈巧巧, consider0911@163.com

DOI：10.12201/bmr.202412.00062

The efficacy of glutamine dipeptide combined with octreotide on patients with acute pancreatitis related lung injury and its impacts on serum TLR4 and MMP-9 levels

• 摘要：摘要：目的 探究丙氨酰谷氨酰胺联合奥曲肽治疗急性胰腺炎（SAP）相关性肺损伤患者的疗效及对血清Toll样受体4（TLR4）、基质金属蛋白酶-9（MMP-9）水平的影响。方法 选取本院2022年6月至2024年6月收治的SAP相关性肺损伤患者94例，随机分为观察组、对照组，对照组奥曲肽治疗，观察组丙氨酰谷氨酰胺治疗（对照组基础上）。比较两组患者的疗效，治疗前后病情严重程度（Balthazar CT评分、APACHE Ⅱ评分、MLIS评分）、血清TLR4、MMP-9、血气指标动脉血氧分压（PaO2）、血氧饱和度（SaO2）和氧合指数的变化情况。结果 观察组疗效更优（P＜0.05）。与治疗前相比，治疗后两组患者Balthazar CT评分、APACHE Ⅱ评分、MLIS评分、血清TLR4、MMP-9水平显著降低，PaO2、SaO2、氧合指数显著升高，且观察组更优（P＜0.05）。结论 丙氨酰谷氨酰胺联合奥曲肽治疗SAP相关性肺损伤患者的效果显著，可以改善患者的临床症状，降低肺损伤状况，抑制炎性反应，改善血气指标，促进患者了恢复。

  关键词： 丙氨酰谷氨酰胺；奥曲肽；急性胰腺炎；相关性肺损伤；疗效；Toll样受体4；基质金属蛋白酶-9; ; ; ; ; ; 

   

  Abstract: Abstract: Objective To investigate the efficacy of the combination of glutamine dipeptide and octreotide in treating severe acute pancreatitis (SAP) - related lung injury patients and their effects on serum Toll like receptor 4 (TLR4) and matrix metalloproteinase-9 (MMP-9) levels. Methods: Ninety-four patients with SAP-associated lung injury admitted to our hospital from June 2022 to June 2024 were selected and randomly divided into an observation group and a control group, with octreotide treatment in the control group and prolylglutamine treatment in the observation group (on the basis of the control group). The efficacy, the changes in severity of the condition (Balthazar CT score, APACHE II score, MLIS score), serum TLR4, MMP-9, and blood gas indicators arterial partial pressure of oxygen (PaO2), blood oxygen saturation (SaO2), and oxygenation index before and after treatment were compared between the two groups. Results The observation group showed better efficacy (P<0.05). Compared with before treatment, the Balthazar CT score, APACHE II score, MLIS score, serum TLR4, MMP-9 levels in both groups obviously decreased after treatment, while PaO2, SaO2, and oxygenation index obviously increased, and the observation group was better (P<0.05). Conclusion: The combination of glutamine dipeptide and octreotide is effective in treating patients with SAP related lung injury, it can improve the clinical symptoms of patients, reduce lung injury, inhibit inflammatory reactions, improve blood gas indicators, and promote patient recovery

  Key words: Glutamine dipeptide; Octreotide; Severe acute pancreatitis; Related lung injury; Efficacy; Toll like receptor 4; Matrix metalloproteinase-9

  提交时间：2024-12-25

  版权声明：作者本人独立拥有该论文的版权，预印本系统仅拥有论文的永久保存权利。任何人未经允许不得重复使用。
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• 序号	提交日期	编号	操作
  1	2024-11-08	bmr.202412.00062V1	下载

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