通讯作者: 蒋雯, 1978896001@qq.com

DOI：10.12201/bmr.202410.00061

The predictive value of serum ALB, CRP, GLB in recurrent diabetes foot ulcer

• 摘要：目的 探讨血清白蛋白(albumin,ALB)、C反应蛋白(C-reactive protein,CRP)、球蛋白(globulin,GLB)对复发性糖尿病足溃疡的预测价值。方法 选取2020年01月至2023年11月武汉市第三医院收治的复发性糖尿病足溃疡59例为复发组,选择相同时间内未出现复发的糖尿病足溃疡患者42例作为对照组,对比两组患者血清ALB、CRP、GLB及肌酐的水平,采用Logistics回归分析检验复发性糖尿病足溃疡的影响因素；绘制受试者工作曲(receiver operating characteristic,ROC曲线)分析血清ALB、CRP及GLB酐对复发性糖尿病足溃疡的预测价值。结果 复发组ALB水平低于对照组(P<0.05),CRP、GLB水平均高于对照组(P<0.05),ALB、CRP、GLB预测复发性糖尿病足溃疡的的曲线下面积(AUC)分别为0.782(95%CI:0.691~0.874)、0.824(95%CI:0.742~0.906)、0.686(95%CI:0.582~0.790),最佳截值分别为38.85g/L、8.31mg/L、32.85g/L,ALB、CRP及GLB联合预测复发性糖尿病足溃疡的AUC为0.849(95%CI:0.775~0.922),高于ALB、CRP、GLB单独预测复发性糖尿病足溃疡的AUC(P<0.05)。结论 复发性糖尿病足溃疡患者血清ALB水平降低,CRP、GLB水平升高；同时ALB、CRP及GLB对复发性糖尿病足溃疡具有一定的预测价值,且三者联合预测复发性糖尿病足溃疡的价值更高。

  关键词： 白蛋白; C反应蛋白; 球蛋白; 溃疡复发; 预测价值

   

  Abstract: Objective To investigate the predictive value of serum albumin (ALB), C-reactive protein (CRP) and globulin (GLB) in recurrent diabetes foot ulcer. Methods From January 2020 to November 2023, 59 patients with recurrent diabetes foot ulcers admitted to the Third Hospital of Wuhan City were selected as the recurrent group, and 42 patients with diabetes foot ulcers that did not recur in the same time were selected as the control group. The serum levels of ALB, CRP, globulin and creatinine of the two groups were compared, and the influencing factors of recurrent diabetes foot ulcers were tested by logistic regression analysis; Draw receiver operating characteristic (ROC curve) to analyze the predictive value of serum ALB, CRP and GLB anhydride on recurrent diabetes foot ulcer. Results The ALB level in the recurrent group was lower than that in the control group (P<0.05), and the CRP and GLB levels were higher than those in the control group (P<0.05). The area under the curve (AUC) of ALB, CRP, and GLB for predicting recurrent diabetes foot ulcer was 0.782 (95% CI: 0.691~0.874), 0.824 (95% CI: 0.742~0.906), and 0.686 (95% CI: 0.582~0.790), respectively. The optimal cutoff values were 38.85g/L, 8.31mg/L, and 32.85g/L, respectively. The AUC of ALB, CRP, and GLB for predicting recurrent diabetes foot ulcer was 0.849 (95% CI: 0.775~0.922), which was higher than that of ALB, CRP and GLB alone in predicting AUC of recurrent diabetes foot ulcer (P<0.05). Conclusion The serum ALB level in patients with recurrent diabetes foot ulcer is decreased, while CRP and GLB levels are increased; At the same time, ALB, CRP and GLB have a certain predictive value for recurrent diabetes foot ulcer, and the combined prediction value of the three is higher for recurrent diabetes foot ulcer.

  Key words: albumin; C-reactive protein; Globulin; Recurrent foot ulcer in diabetes: predictive value; 

  提交时间：2024-10-23

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• 序号	提交日期	编号	操作
  1	2024-09-07	bmr.202410.00061V1	下载

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