Impact of the national centralized drug procurement policy on drug prices and utilization: a systematic review

Corresponding author: ZHU He, he.zhu@pku.edu.cn

DOI: 10.12201/bmr.202303.00033

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  Abstract: Objective: To evaluate the impact of the national centralized drug procurement policy on drug prices and utilization. Methods: A systematic review approach was applied to search six databases: China Knowledge Network (CNKI), WanFang (WanFang Data), Vipshop (VIP), EMbase, PubMed, and Web of Science, and empirical findings were extracted and analyzed. Results: A total of 58 studies were included, and most of them found a significant decrease in the defined daily cost (DDC) of the selected drugs after the implementation of the national centralized drug procurement policy, as well as a decrease in similar nonselected drugs’s DDC. For example, hepatitis drugs’ DDC showed a significant decrease. The Defined daily doses (DDDs) of generic drugs increased significantly overall, achieving partial domestic substitution for the original drugs. For example, DDDs of most drugs related to cardiovascular diseases increased significantly. However, there were some regional differences in the implementation effect of the national centralized drug procurement policy and the phenomenon of price decoupling, which need to be further strengthened and improved. Conclusion: According to previously empirical findings of policy effects, the policy goals have been achieved initially, and it is recommended to continue to work on promoting the equalization of low-priced and high-quality drugs and increasing the policy publicity and the monitor of drug quality and price.

  Key words: National Centralized Drug Procurement Policy；Defined daily doses (DDDs)；Defined daily cost (DDC); Systematic review; ; 

  Submit time: 23 March 2023

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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