Clinical application study of different doses of remimazolam in ultrasound-guided caudal block for hemorrhoidectomyLIU Tao,Zhang Hui,XIE Chen,Department of Anesthesiology,First People’s Hospital of Huzhou,Huzhou 313000,CHINA

Corresponding author: Xie Chen, hzyyxc@163.com

DOI: 10.12201/bmr.202411.00025

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  Abstract: Objective: To explore the sedative effects of different doses of remimazolam in ultrasound-guided caudal block hemorrhoidectomy and its impact on hemodynamics. Methods: A total of 90 patients undergoing ultrasound-guided caudal block hemorrhoidectomy from June 2023 to May 2024 were selected and randomly divided into three groups (A, B, C), with 30 cases in each group. Remimazolam was administered via intravenous pump at doses of 0.2, 0.3, and 0.5 mg/(kg·h) for sedation. The sedative effects among the three groups were compared, and changes in mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SPO2), and respiratory rate (RR) were recorded at baseline (T0), immediately after administration (T1), during anal dilation (T2), during hemorrhoidectomy (T3), at the end of surgery (T4), and at awakening (T5). The occurrence of adverse reactions in the three groups was also recorded. Results: Compared to group C, groups A and B had shorter sedation awakening times and higher sedation success rates, with statistically significant differences (P < 0.05). Compared to T0, MAP, RR, and SPO2 decreased in all three groups at T1-T4, and HR decreased at T3-T5 (P < 0.05). There were no significant differences in MAP and HR among the three groups (P > 0.05), but significant differences were observed in SPO2 and RR at the same time points (P < 0.05). The incidence of adverse reactions in group C was higher than in groups A and B, with statistically significant differences (P < 0.05). There was no statistically significant difference between groups A and B (P > 0.05). Conclusion: Remimazolam provides satisfactory sedation in ultrasound-guided caudal block hemorrhoidectomy, has minimal impact on hemodynamics, and is safe, with a recommended optimal dose of 0.3 mg/(kg·h).
  Keywords:Remimazolam; ultrasound-guided; caudal block; hemorrhoidectomy; sedative effect

  Key words: Remimazolam; ultrasound-guided; caudal block; hemorrhoidectomy; sedative effect

  Submit time: 11 November 2024

  Copyright: The copyright holder for this preprint is the author/funder, who has granted biomedRxiv a license to display the preprint in perpetuity.
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